In Vitro and In Vivo Chaperone Effect of (R)-2-amino-6-(1R, 2S)-1, 2-dihydroxypropyl)-5, 6, 7, 8-tetrahydropterin-4 (3H)-one on the C1473G Mutant Tryptophan …
AB Arefieva, PD Komleva, VS Naumenko, NV Khotskin… - Biomolecules, 2023 - mdpi.com
Tryptophan hydroxylase 2 (TPH2) is the key and rate-limiting enzyme of serotonin (5-HT)
synthesis in the mammalian brain. The 1473G mutation in the Tph2 gene decreases TPH2 …
synthesis in the mammalian brain. The 1473G mutation in the Tph2 gene decreases TPH2 …
Effect of (R)-2-Amino-6-(1R, 2S)-1, 2-Dihydroxypropyl)-5, 6, 7, 8-Tetrahydropterin-4 (3H)-One and Its Structural Analogues on the Temperature Stability of Tryptophan …
AB Arefieva, PD Komleva, M Gubina… - Bulletin of Experimental …, 2024 - Springer
The enzyme tryptophan hydroxylase 2 (TPH2) catalyzes the hydroxylation of L-tryptophan to
L-5-hydroxytryptophan (5-HTP), the first and the key step in 5-HT synthesis in the …
L-5-hydroxytryptophan (5-HTP), the first and the key step in 5-HT synthesis in the …
Stabilization of tryptophan hydroxylase 2 by l‐phenylalanine‐induced dimerization
KD Tidemand, HEM Christensen, N Hoeck… - FEBS Open …, 2016 - Wiley Online Library
Tryptophan hydroxylase 2 (TPH 2) catalyses the initial and rate‐limiting step in the
biosynthesis of serotonin, which is associated with a variety of disorders such as depression …
biosynthesis of serotonin, which is associated with a variety of disorders such as depression …
Characterization of wild‐type and mutant forms of human tryptophan hydroxylase 2
I Winge, JA McKinney, PM Knappskog… - Journal of …, 2007 - Wiley Online Library
Tryptophan hydroxylase (TPH) catalyses the rate‐limiting step in the biosynthesis of
serotonin. In vertebrates, the homologous genes tph1 and tph2 encode two different …
serotonin. In vertebrates, the homologous genes tph1 and tph2 encode two different …
Effect of pharmacological chaperones on brain tyrosine hydroxylase and tryptophan hydroxylase 2
J. Neurochem.(2010) 114, 853–863. Abstract Phenylalanine hydroxylase (PAH), tyrosine
hydroxylase (TH) and the tryptophan hydroxylases (TPH1 and TPH2) are structurally and …
hydroxylase (TH) and the tryptophan hydroxylases (TPH1 and TPH2) are structurally and …
Influence of human tryptophan hydroxylase 2 N‐and C‐terminus on enzymatic activity and oligomerization
K Tenner, D Walther, M Bader - Journal of neurochemistry, 2007 - Wiley Online Library
Tryptophan hydroxylase (TPH) catalyses the first and rate limiting step in the biosynthesis of
the neurotransmitter serotonin. There are two TPH isoenzymes in humans, encoded by two …
the neurotransmitter serotonin. There are two TPH isoenzymes in humans, encoded by two …
Isoform-specific substrate inhibition mechanism of human tryptophan hydroxylase
KD Tidemand, GH Peters, P Harris, E Stensgaard… - Biochemistry, 2017 - ACS Publications
Tryptophan hydroxylase (TPH) catalyzes the initial and rate-limiting step in the biosynthesis
of serotonin, which is associated with a variety of disorders such as depression and irritable …
of serotonin, which is associated with a variety of disorders such as depression and irritable …
Functional domains of human tryptophan hydroxylase 2 (hTPH2)
Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in serotonin biosynthesis. A novel
gene, termed TPH2, has recently been described. This gene is preferentially expressed in …
gene, termed TPH2, has recently been described. This gene is preferentially expressed in …
Comprehensive behavioral analysis and quantification of brain free amino acids of C57 BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase‐2
H Koshimizu, N Hirata, K Takao… - …, 2019 - Wiley Online Library
Abstract Aim Tryptophan hydroxylase 2 (Tph2) is a rate‐limiting enzyme for the biosynthesis
of 5‐hydroxytryptamine (5‐HT, serotonin). Previous studies have reported that C1473G …
of 5‐hydroxytryptamine (5‐HT, serotonin). Previous studies have reported that C1473G …
Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels
K Nakamura, Y Sugawara, K Sawabe… - Journal of …, 2006 - Soc Neuroscience
Serotonin [5-hydroxytryptamine (5-HT)] is a major therapeutic target of psychiatric disorders.
Tryptophan hydroxylase (TPH) catalyzes the rate-limiting reaction in the biosynthesis of 5 …
Tryptophan hydroxylase (TPH) catalyzes the rate-limiting reaction in the biosynthesis of 5 …