Pulmonary hypertension in heart failure: pathophysiology, pathobiology, and emerging clinical perspectives

M Guazzi, R Naeije - Journal of the American College of Cardiology, 2017 - jacc.org
Pulmonary hypertension is a common hemodynamic complication of heart failure. Interest in
left-sided pulmonary hypertension has increased remarkably in recent years because its …

Pulmonary hypertension due to left heart disease

M Guazzi, BA Borlaug - Circulation, 2012 - Am Heart Assoc
Pulmonary hypertension (PH) due to left heart disease, classified as group 2 according to
the Dana Point 2008 classification, is believed to be the most common cause of PH and is …

Pulmonary hypertension in heart failure. Epidemiology, right ventricular function, and survival

M Gerges, C Gerges, AM Pistritto, MB Lang… - American journal of …, 2015 - atsjournals.org
Rationale: Patients with pulmonary hypertension due to left heart disease (PH-LHD) and a
diastolic pulmonary vascular pressure gradient≥ 7 mm Hg, representing PH out of …

Right heart failure in pulmonary hypertension

SJ Cassady, GV Ramani - Cardiology clinics, 2020 - cardiology.theclinics.com
Pulmonary hypertension (PH), previously defined as a mean pulmonary artery pressure of
greater than 25 mm Hg, has recently been redefined by the Sixth World Symposium on …

Systemic consequences of pulmonary hypertension and right-sided heart failure

S Rosenkranz, LS Howard, M Gomberg-Maitland… - Circulation, 2020 - Am Heart Assoc
Pulmonary hypertension (PH) is a feature of a variety of diseases and continues to harbor
high morbidity and mortality. The main consequence of PH is right-sided heart failure which …

Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology

A Vonk-Noordegraaf, F Haddad, KM Chin… - Journal of the American …, 2013 - jacc.org
Survival in patients with pulmonary arterial hypertension (PAH) is closely related to right
ventricular (RV) function. Although pulmonary load is an important determinant of RV …

Pulmonary hypertension with left-sided heart disease

M Guazzi, R Arena - Nature Reviews Cardiology, 2010 - nature.com
Pulmonary hypertension (PH) with left-sided heart disease is defined, according to the latest
Venice classification, as a Group 2 PH, which includes left-sided ventricular or atrial disease …

Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension: an update

AV Noordegraaf, KM Chin, F Haddad… - European …, 2019 - Eur Respiratory Soc
The function of the right ventricle determines the fate of patients with pulmonary
hypertension. Since right heart failure is the consequence of increased afterload, a full …

The role of the right ventricle in pulmonary arterial hypertension

AV Noordegraaf, N Galiè - European Respiratory Review, 2011 - Eur Respiratory Soc
Although changes in the pulmonary vasculature are the primary cause of pulmonary arterial
hypertension (PAH), severity of symptoms and survival are strongly associated with right …

World Health Organization Pulmonary Hypertension group 2: pulmonary hypertension due to left heart disease in the adult—a summary statement from the Pulmonary …

JC Fang, T DeMarco, MM Givertz, BA Borlaug… - The Journal of heart and …, 2012 - Elsevier
Pulmonary hypertension associated with left heart disease is the most common form of
pulmonary hypertension encountered in clinical practice today. Although frequently a target …