[HTML][HTML] Cancer-associated fibroblasts suppress ferroptosis and induce gemcitabine resistance in pancreatic cancer cells by secreting exosome-derived ACSL4 …
R Qi, Y Bai, K Li, N Liu, Y Xu, E Dal, Y Wang… - Drug Resistance …, 2023 - Elsevier
Background Pancreatic cancer continues to be one of the world's most lethal cancers.
Chemotherapy resistance in patients with advanced pancreatic cancer often accompany …
Chemotherapy resistance in patients with advanced pancreatic cancer often accompany …
Exosomal lncRNA UCA1 Derived From Pancreatic Stellate Cells Promotes Gemcitabine Resistance in Pancreatic Cancer via the SOCS3/EZH2 Axis
Y Chi, H Xin, Z Liu - Frontiers in Oncology, 2021 - frontiersin.org
Objective Pancreatic cancer is associated with poor prognosis and dismal survival rates.
This study aims to investigate roles of lncRNA UCA1-loaded exosomes secreted by …
This study aims to investigate roles of lncRNA UCA1-loaded exosomes secreted by …
[HTML][HTML] Exosomal miRNA-106b from cancer-associated fibroblast promotes gemcitabine resistance in pancreatic cancer
Y Fang, W Zhou, Y Rong, T Kuang, X Xu, W Wu… - Experimental cell …, 2019 - Elsevier
Gemcitabine (GEM)-based chemotherapy is commonly used to treat pancreatic cancer.
However, acquired resistance to GEM remains a challenge in pancreatic cancer patients …
However, acquired resistance to GEM remains a challenge in pancreatic cancer patients …
Exosomes derived from cancer stem cells of gemcitabine-resistant pancreatic cancer cells enhance drug resistance by delivering miR-210
Z Yang, N Zhao, J Cui, H Wu, J Xiong, T Peng - Cellular Oncology, 2020 - Springer
Purpose Gemcitabine (GEM)-based chemotherapy is the first-line treatment for locally
advanced pancreatic cancer. GEM resistance, however, remains a significant clinical …
advanced pancreatic cancer. GEM resistance, however, remains a significant clinical …
Adipose mesenchymal stem cell-derived exosomal microRNA-1236 reduces resistance of breast cancer cells to cisplatin by suppressing SLC9A1 and the Wnt/β …
Z Jia, H Zhu, H Sun, Y Hua, G Zhang… - Cancer Management …, 2020 - Taylor & Francis
Background Emerging evidence has noted the versatile functions of mesenchymal stem cell-
derived exosomes (MSC-Exos) in cancer control. This work aims to probe to function of …
derived exosomes (MSC-Exos) in cancer control. This work aims to probe to function of …
Exosomal miR-4443 promotes cisplatin resistance in non-small cell lung carcinoma by regulating FSP1 m6A modification-mediated ferroptosis
Z Song, G Jia, P Ma, S Cang - Life sciences, 2021 - Elsevier
Aims Exosomal transfer of miRNAs affects recipient cell proliferation and chemoresistance.
Here, we aimed to investigate the role of exosomal miRNAs in controlling cisplatin …
Here, we aimed to investigate the role of exosomal miRNAs in controlling cisplatin …
SLC38A5 modulates ferroptosis to overcome gemcitabine resistance in pancreatic cancer
MJ Kim, HS Kim, HW Kang, DE Lee, WC Hong, JH Kim… - Cells, 2023 - mdpi.com
Pancreatic cancer is characterized by a poor prognosis, with its five-year survival rate lower
than that of any other cancer type. Gemcitabine, a standard treatment for pancreatic cancer …
than that of any other cancer type. Gemcitabine, a standard treatment for pancreatic cancer …
CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer
H Zhang, T Deng, R Liu, T Ning, H Yang, D Liu… - Molecular cancer, 2020 - Springer
Background Ferroptosis is a novel mode of non-apoptotic cell death induced by build-up of
toxic lipid peroxides (lipid-ROS) in an iron dependent manner. Cancer-associated …
toxic lipid peroxides (lipid-ROS) in an iron dependent manner. Cancer-associated …
Cancer-associated fibroblasts confer gemcitabine resistance to pancreatic cancer cells through PTEN-targeting miRNAs in exosomes
Simple Summary Previous studies have shown that cancer associated fibroblasts exposed
to chemotherapy release exosomes which promote chemoresistance in recipient cells …
to chemotherapy release exosomes which promote chemoresistance in recipient cells …
Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells
KE Richards, AE Zeleniak, ML Fishel, J Wu… - Oncogene, 2017 - nature.com
Cancer-associated fibroblasts (CAFs) comprise the majority of the tumor bulk of pancreatic
ductal adenocarcinomas (PDACs). Current efforts to eradicate these tumors focus …
ductal adenocarcinomas (PDACs). Current efforts to eradicate these tumors focus …
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