Background Pancreatic cancer continues to be one of the world's most lethal cancers.
Chemotherapy resistance in patients with advanced pancreatic cancer often accompany …

Objective Pancreatic cancer is associated with poor prognosis and dismal survival rates.
This study aims to investigate roles of lncRNA UCA1-loaded exosomes secreted by …

Gemcitabine (GEM)-based chemotherapy is commonly used to treat pancreatic cancer.
However, acquired resistance to GEM remains a challenge in pancreatic cancer patients …

Purpose Gemcitabine (GEM)-based chemotherapy is the first-line treatment for locally
advanced pancreatic cancer. GEM resistance, however, remains a significant clinical …

Background Emerging evidence has noted the versatile functions of mesenchymal stem cell-
derived exosomes (MSC-Exos) in cancer control. This work aims to probe to function of …

Aims Exosomal transfer of miRNAs affects recipient cell proliferation and chemoresistance.
Here, we aimed to investigate the role of exosomal miRNAs in controlling cisplatin …

Pancreatic cancer is characterized by a poor prognosis, with its five-year survival rate lower
than that of any other cancer type. Gemcitabine, a standard treatment for pancreatic cancer …

Background Ferroptosis is a novel mode of non-apoptotic cell death induced by build-up of
toxic lipid peroxides (lipid-ROS) in an iron dependent manner. Cancer-associated …

Simple Summary Previous studies have shown that cancer associated fibroblasts exposed
to chemotherapy release exosomes which promote chemoresistance in recipient cells …

Cancer-associated fibroblasts (CAFs) comprise the majority of the tumor bulk of pancreatic
ductal adenocarcinomas (PDACs). Current efforts to eradicate these tumors focus …