Background Susceptibility to infection is in part genetically driven, and C57BL/6 mice resist
various pathogens through the proinflammatory response of their M1 macrophages (MPs) …

Background. Although laboratory mice are usually highly susceptible to Yersinia pestis, we
recently identified a mouse strain (SEG) that exhibited an exceptional capacity to resist …

The virulence protein YopM of the plague bacterium Yersinia pestis has different dominant
effects in liver and spleen. Previous studies focused on spleen, where YopM inhibits …

Yersinia pestis, the etiologic agent of plague, delivers six Yersinia outer proteins (Yops) into
host cells upon direct bacterial contact. One of these, YopM, is necessary for virulence in a …

We are using a systemic plague model to identify the cells and pathways that are
undermined by the virulence protein YopM of the plague bacterium Yersinia pestis. In this …

Review of infected macrophages undergoing pyroptosis as a host-healthy alternative to
apoptosis. Yersinia pestis, the etiological agent of plague, is one of the most deadly …

Yersinia pestis causes bubonic, pneumonic, and septicemic plague. Although no longer
responsible for pandemic outbreaks, pneumonic plague continues to be a challenge for …

Laboratory mice are well known to be highly susceptible to virulent strains of Yersinia pestis
in experimental models of bubonic plague. We have found that Mus spretus-derived …

Although lipopolysaccharide (LPS) stimulation through the Toll-like receptor (TLR)-4/MD-2
receptor complex activates host defense against Gram-negative bacterial pathogens, how …

We recently characterized the Δlpp Δpla double in-frame deletion mutant of Yersinia pestis
CO92 molecularly, biologically, and immunologically. While Braun lipoprotein (Lpp) …