Long-term culture of purified postnatal oligodendrocyte precursor cells: evidence for an intrinsic maturation program that plays out over months

DG Tang, YM Tokumoto, MC Raff - The Journal of cell biology, 2000 - rupress.org
Oligodendrocytes myelinate axons in the vertebrate central nervous system (CNS). They
develop from precursor cells (OPCs), some of which persist in the adult CNS. Adult OPCs …

Cell size control and a cell-intrinsic maturation program in proliferating oligodendrocyte precursor cells

FB Gao, M Raff - The Journal of cell biology, 1997 - rupress.org
We have used clonal analysis and time-lapse video recording to study the proliferative
behavior of purified oligodendrocyte precursor cells isolated from the perinatal rat optic …

Purification and characterization of adult oligodendrocyte precursor cells from the rat optic nerve

J Shi, A Marinovich, BA Barres - Journal of Neuroscience, 1998 - Soc Neuroscience
Oligodendrocyte precursor cells (OPCs) persist in substantial numbers in the adult brain in a
quiescent state suggesting that they may provide a source of new oligodendrocytes after …

Normal timing of oligodendrocyte development from genetically engineered, lineage-selectable mouse ES cells

N Billon, C Jolicoeur, QL Ying, A Smith… - Journal of Cell …, 2002 - journals.biologists.com
Oligodendrocytes are post-mitotic cells that myelinate axons in the vertebrate central
nervous system (CNS). They develop from proliferating oligodendrocyte precursor cells …

Astrocytes promote neurogenesis from oligodendrocyte precursor cells

PM Gaughwin, MA Caldwell… - European Journal of …, 2006 - Wiley Online Library
The oligodendrocyte precursor cell (OPC) has until recently been regarded as a lineage‐
restricted precursor cell. Considerable interest has been generated by reports suggesting …

Control of oligodendrocyte number in the developing rat optic nerve

BA Barres, MC Raff - Neuron, 1994 - Elsevier
The only known function of oligodendrocytes is to myelinate axons in the vertebrate CNS. In
this review, we consider how the number of oligodendrocytes is matched during …

Human oligodendrocyte precursor cells in vitro: phenotypic analysis and differential response to growth factors

HC Wilson, C Onischke, CS Raine - Glia, 2003 - Wiley Online Library
Following experimental demyelination in rodents, oligodendrocyte precursor cells (OPCs)
proliferate and differentiate into myelin‐producing oligodendrocytes which effect robust …

Axonal control of oligodendrocyte development

BA Barres, MC Raff - The Journal of cell biology, 1999 - rupress.org
HOW are the numbers of different cell types matched together during tissue development?
The nervous system has provided an excellent model system for understanding this …

Oligodendrocyte precursor cells from different brain regions express divergent properties consistent with the differing time courses of myelination in these regions

J Power, M Mayer-Pröschel, J Smith, M Noble - Developmental biology, 2002 - Elsevier
Different CNS regions exhibit different temporal patterns of oligodendrocyte generation and
myelinogenesis. Characterization of oligodendrocyte-type-2 astrocyte progenitor cells (here …

Differentiation and death of premyelinating oligodendrocytes in developing rodent brain

BD Trapp, A Nishiyama, D Cheng… - The Journal of cell …, 1997 - rupress.org
Previous studies have indicated that newly formed oligodendrocytes are dynamic cells
whose production, survival, and differentiation depend upon axonal influences. This study …