SUMMARY 1 After an outline description of pancreatic structure and function, and a more
detailed account of acinar cell morphology, this review traces the pathway of amino acids as …

Radioautographs of pancreatic acinar cells were prepared in rats and mice sacrificed at
various times after injection of leucine-, glycine-, or methionine-H3. Measurements of …

Experiments have been carried out to determine whether intracellular transport of pancreatic
secretory proteins is obligatorily coupled to protein synthesis or whether it is a separable …

Our previous observations on the synthesis and transport of secretory proteins in the
pancreatic exocrine cell were made on pancreatic slices from starved guinea pigs and …

The rate of synthesis and the turnover of cytoplasmic membrane proteins were determined
in the acinar cells of guinea pig pancreas with the aim of investigating the mechanisms by …

Since in the pancreatic exocrine cell synthesis and intracellular transport of secretory
proteins can be uncoupled (1), it is possible to examine separately the metabolic …

The secretion of protein by the acinar cells of the pancreas occurs in two steps: the synthesis
of the protein from amino acids and its migration through the cell to the acinar lumen. Since …

It has been established by electron microscopic radioautography of guinea pig pancreatic
exocrine cells (Caro and Palade, 1964) that secretory proteins are transported from the …

Prolonged secretory stimulation of the exocrine pancreas in the rat by in vivo infusion of
caerulein leads to a rapid degranulation of the organ associated with a progressive …

The effect of temperature on secretory protein transport was studied by cell fractionation of
rat pancreatic lobules, pulse-labeled in vitro with [35S] methionine and chased for 60 min at …