[HTML][HTML] Mesenchymal stem cell-derived exosomes regulate the polarization and inflammatory response of macrophages via miR-21-5p to promote repair after …

D Shen, Z He - Annals of translational medicine, 2021 - ncbi.nlm.nih.gov
Background Myocardial ischemia-reperfusion injury is a type of myocardial ischemia that
has a significant impact on patients' health. We aimed to explore the protective effect of …

Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization

J Zhao, X Li, J Hu, F Chen, S Qiao, X Sun… - Cardiovascular …, 2019 - academic.oup.com
Abstract Aims Mesenchymal stromal cells (MSCs) gradually become attractive candidates
for cardiac inflammation modulation, yet understanding of the mechanism remains elusive …

[HTML][HTML] BMSC‑derived exosome‑mediated miR‑25‑3p delivery protects against myocardial ischemia/reperfusion injury by constraining M1‑like macrophage …

J Du, Y Dong, J Song, H Shui… - Molecular …, 2024 - spandidos-publications.com
Myocardial ischemia/reperfusion injury (MIRI) is a significant challenge in the management
of myocardial ischemic disease. Extensive evidence suggests that the macrophage …

Exosomes Derived from miR‐146a‐5p‐Enriched Mesenchymal Stem Cells Protect the Cardiomyocytes and Myocardial Tissues in the Polymicrobial Sepsis through …

C Liu, J Xue, B Xu, A Zhang, L Qin, J Liu… - Stem cells …, 2021 - Wiley Online Library
Background. At present, the study has confirmed that the mesenchymal stem cell‐derived
exosomes (MCSs‐Exo) possess cardio‐protection in sepsis. Nevertheless, the molecular …

Nicorandil-Pretreated Mesenchymal Stem Cell-Derived Exosomes Facilitate Cardiac Repair After Myocardial Infarction via Promoting Macrophage M2 Polarization by …

ZT Gong, YY Xiong, Y Ning, RJ Tang… - International Journal …, 2024 - Taylor & Francis
Background Exosomes derived from bone marrow mesenchymal stem cells (MSC-exo) have
been considered as a promising cell-free therapeutic strategy for ischemic heart disease …

Exosomes derived from pro‐inflammatory bone marrow‐derived mesenchymal stem cells reduce inflammation and myocardial injury via mediating macrophage …

R Xu, F Zhang, R Chai, W Zhou, M Hu… - Journal of cellular …, 2019 - Wiley Online Library
Exosomes are served as substitutes for stem cell therapy, playing important roles in
mediating heart repair during myocardial infarction injury. Evidence have indicated that …

Mesenchymal stem cell-derived exosomal miR-143-3p suppresses myocardial ischemia-reperfusion injury by regulating autophagy

G Chen, M Wang, Z Ruan, L Zhu, C Tang - Life sciences, 2021 - Elsevier
Aims Myocardial ischemia-reperfusion (I/R) injury is considered as a major obstacle of
myocardial perfusion to save acute myocardial infarction, and causes a serious threat to …

Exosomes derived from mir-214-3p overexpressing mesenchymal stem cells promote myocardial repair

W Zhu, Q Wang, J Zhang, L Sun, X Hong… - Biomaterials …, 2023 - spj.science.org
Aims Exosomes are known as nanovesicles that are naturally secreted, playing an essential
role in stem-mediated cardioprotection. This study mainly focused on investigating if …

M2 macrophage-derived exosomes carry miR-1271-5p to alleviate cardiac injury in acute myocardial infarction through down-regulating SOX6

R Long, L Gao, Y Li, G Li, P Qin, Z Wei, D Li, C Qian… - Molecular …, 2021 - Elsevier
Background Emerging evidence has indicated that exosomes serve as key regulators in
acute myocardial infarction (AMI). This study was determined to investigate the effect of M2 …

[PDF][PDF] Lipopolysaccharide-stimulated bone marrow mesenchymal stem cells-derived exosomes inhibit H2O2-induced cardiomyocyte inflammation and oxidative …

HY Liu, LF Yu, TG Zhou, YD Wang… - European Review for …, 2020 - europeanreview.org
OBJECTIVE: Myocardial infarction (MI) is a cardiovascular disease that seriously endangers
human health. Exosomes secreted by stem cells have big potential for the treatment of many …