The exposure of cells, tissues and extracellular matrix to harmful reactive species causes a
cascade of reactions and induces activation of multiple internal defence mechanisms …

In this modern world, due to the rapid advancement of civilization, industrialization, and
overpopulation, scientific knowledge on antioxidants is important since most of the dis …

The body encloses a complex antioxidant defence grid that relies on endogenous enzymatic
and nonenzymatic antioxidants. These molecules collectively act against free radicals to …

All living organisms are constantly exposed to oxidant agents deriving from both endog-
enous and exogenous sources capable to modify biomolecules and induce damages. Free …

Free radical generation occurs continuously within cells as a consequence of common
metabolic processes. However, in high concentrations, whether from endogenous or …

During normal metabolic functions, highly reactive compounds called free radicals are
generated in the body; however, they may also be introduced from the environment. These …

A number of reactive oxygen and nitrogen species are produced during normal metabolism
in human body. These species can be both radical and non-radical and have varying …

(HO•), consist of radical and non-radical oxygen species formed by the partial reduction of
oxygen. The accumulation of ROS in cells may cause damage of nucleic acids, proteins …

Reactive oxygen species are implicated in the pathogenesis of certain human diseases,
including atherosclerosis, cancer, rheumatoid arthritis, drug-associated toxicity, and …

Present article gives a holistic view of the causes, role and conrol of oxidative stress in the
development and progression of various human diseases. Several types of reactive species …