A spheroid is an in vitro multicellular aggregate that provides a microenvironment
resembling that of normal tissue in vivo. Although cell adhesion molecules such as integrins …

Spheroids resemble features of tissues and serve as model systems to study cell–cell and
cell–ECM interactions in non-adhesive three-dimensional environments. Although it is …

Cultured rat hepatocytes self‐assemble into three‐dimensional structures or spheroids that
exhibit ultrastructural characteristics of native hepatic tissue and enhanced liver‐specific …

Many cell lines derived from solid cancers can form spheroids, which recapitulate tumor cell
clusters and are more representative of the in vivo situation than 2D cultures. During …

Cultured hepatocytes typically form multicellular aggregates which are either monolayered
or spheroidal in morphology. We propose that the aggregate morphology resulting from a …

Deciphering the multifactorial determinants of tumor progression requires standardized high-
throughput preparation of 3D in vitro cellular assays. We present a simple microfluidic …

In epithelia, adhesive interactions participate in specific histogenetic events and also instate
a morphological polarization that is linked to the vectorial functioning of the epithelium. Cell …

Functional tissue architecture originates by self-assembly of distinct cell types, following
tissue-specific rules of cell-cell interactions. In the liver, a structural model of the lobule was …

Recapitulating the tumor microenvironment is a central challenge in the development of
experimental model for cancer. To provide a reliable tool for drug development and for …

Hepatocytes self-assemble in culture to form compacted spherical aggregates, or spheroids,
that mimic the structure of the liver by forming tight junctions and bile canalicular channels …