Latent reservoirs for HIV-1
Combination therapy for HIV-1 infection can reduce viremia to undetectable levels,
suggesting that prolonged treatment might eradicate the infection. However, one potential …
suggesting that prolonged treatment might eradicate the infection. However, one potential …
The latent reservoir for HIV-1: how immunologic memory and clonal expansion contribute to HIV-1 persistence
Combination antiretroviral therapy (ART) for HIV-1 infection reduces plasma virus levels to
below the limit of detection of clinical assays. However, even with prolonged suppression of …
below the limit of detection of clinical assays. However, even with prolonged suppression of …
Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
D Finzi, J Blankson, JD Siliciano, JB Margolick… - Nature medicine, 1999 - nature.com
Combination therapy for HIV-1 infection can reduce plasma virus to undetectable levels,
indicating that prolonged treatment might eradicate the infection. However, HIV-1 can persist …
indicating that prolonged treatment might eradicate the infection. However, HIV-1 can persist …
Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
JD Siliciano, J Kajdas, D Finzi, TC Quinn… - Nature medicine, 2003 - nature.com
Latent HIV-1 persists in resting memory CD4+ T cells, even in patients receiving highly
active antiretroviral therapy (HAART). It has been unclear how stable this latent reservoir is …
active antiretroviral therapy (HAART). It has been unclear how stable this latent reservoir is …
Reservoirs for HIV-1: mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy
T Pierson, J McArthur… - Annual review of …, 2000 - annualreviews.org
The success of combination antiretroviral therapy for HIV-1 infection has generated interest
in mechanisms by which the virus can persist in the body despite the presence of drugs that …
in mechanisms by which the virus can persist in the body despite the presence of drugs that …
Latency in human immunodeficiency virus type 1 infection: no easy answers
For some viruses, long-term persistence in the host depends on the establishment of
latency, a reversibly nonproductive state of infection. The alphaherpesviruses provide a …
latency, a reversibly nonproductive state of infection. The alphaherpesviruses provide a …
A long-term latent reservoir for HIV-1: discovery and clinical implications
JD Siliciano, RF Siliciano - Journal of Antimicrobial …, 2004 - academic.oup.com
Despite the remarkable success of highly active antiretroviral therapy (HAART) for the
treatment of HIV-1 infection, it now appears that the infection is intrinsically incurable with …
treatment of HIV-1 infection, it now appears that the infection is intrinsically incurable with …
From reactivation of latent HIV‐1 to elimination of the latent reservoir: the presence of multiple barriers to viral eradication
L Shan, RF Siliciano - Bioessays, 2013 - Wiley Online Library
The discovery of a stable latent reservoir for HIV‐1 in resting memory CD4+ T cells provides
a mechanism for lifelong persistence of HIV‐1. The long‐lived latently infected cells persist …
a mechanism for lifelong persistence of HIV‐1. The long‐lived latently infected cells persist …
Can antiretroviral therapy ever be stopped?
R Siliciano - The AIDS Reader, 2000 - europepmc.org
A pool of latently infected CD4+ T cells is established within the first few weeks of HIV
infection. Because these memory T cells are inactive, the viral DNA integrated into their …
infection. Because these memory T cells are inactive, the viral DNA integrated into their …
A reservoir for HIV in patients on combination antiretroviral therapy
RF Siliciano - The Hopkins HIV report: a bimonthly …, 1998 - pubmed.ncbi.nlm.nih.gov
AIDS: Research has changed the approach to AIDS therapy, in part by suggesting that
eradication of the virus may be possible with highly active antiretroviral therapy (HAART) …
eradication of the virus may be possible with highly active antiretroviral therapy (HAART) …