RUNX2 is a master transcription factor of osteoblast differentiation. RUNX2 expression in the
bone and osteogenic front of a suture is crucial for cranial suture closure and membranous …

The Runx2 gene product is essential for mammalian bone development. In humans, Runx2
haploinsufficiency results in cleidocranial dysplasia, a skeletal disorder characterized by …

Runx2 is a key transcription factor in osteoblast differentiation, and its activity is regulated by
fibroblast growth factors (FGFs). Craniosynostosis, characterized by premature suture …

RUNX2 is an essential transcription factor for osteoblast differentiation, because osteoblast
differentiation is completely blocked in Runx2-deficient mice. However, it remains to be …

Runt-related transcription factor 2 (RUNX2) is a key transcription factor for bone formation
and osteoblast differentiation. Various signaling pathways and mechanisms that regulate the …

During the last 10 years, we have witnessed major progress in skeleton biology. Runx2 is an
accepted transcription factor essential for osteoblast development from mesenchymal stem …

Runx2 is a master transcription factor for osteogenesis. The most important phenomenon
that makes this protein a master regulator for osteogenesis is its structural integrity. In …

Runx2 is essential for osteoblast differentiation and chondrocyte maturation. During
osteoblast differentiation, Runx2 is weakly expressed in uncommitted mesenchymal cells …

Runx2 is a key transcription factor regulating osteoblast differentiation and skeletal
morphogenesis, and FGF2 is one of the most important regulators of skeletal development …

Skeletogenesis occurs through either intramembranous or endochondral ossification. In
addition, some parts of the skeletal components maintain their cartilaginous characteristics …