The purpose of this work was to investigate key factors dictating the success/failure of
cyclodextrin-based solubility-enabling formulations for oral delivery of low-solubility drugs …

When administered orally, the bioavailability of drugs is strongly influenced by their aqueous
solubility and permeability. Although solubility-enabling excipients can improve the aqueous …

The purpose of this study was to investigate the impact of oral cyclodextrin-based
formulation on both the apparent solubility and intestinal permeability of lipophilic drugs. The …

We aimed to understand the impact of the interplay between bile salts and cyclodextrins on
the dissolution-permeation of poorly soluble drug compounds with a moderate-strong …

Although the extraordinary solubility advantage afforded by cyclodextrins has led to their
widespread use as pharmaceutical solubilizers, several reports have emerged that …

Recently, we have revealed a trade-off between solubility increase and permeability
decrease when solubility-enabling oral formulations are employed. We have shown this …

Introduction Tackling low water solubility of drug candidates is a major challenge in today's
pharmaceutics/biopharmaceutics, especially by means of modern solubility-enabling …

The main factors influencing the absorption of orally administered drugs are solubility and
permeability, which are location-dependent and may vary along the gastrointestinal tract …

The aim of the current work was to investigate the key factors that govern the success/failure
of an ethanol-based solubility-enabling oral drug formulation, including the effects of the …

The ability to quantitatively predict the influence of a solubilization technology on oral
absorption would be highly beneficial in rational selection of drug delivery technology and …