Late-stage modification of peptides and proteins meets the increasing demand in
biochemical and pharmaceutical communities. These modification strategies could provide …

The growing importance of peptides and proteins in therapeutic and biomedical applications
has provided immense motivation toward the development of new ways to construct and …

Amino acids and peptides play an important role in nature as well as in the pharmaceutical
industry. Therefore, transformation of amino acids and peptides into their unnatural …

Amino acids and peptides play an important role in nature, as well as in organic and
pharmaceutical chemistry. Therefore, the easy, straightforward and versatile access of …

The applications of peptides and peptidomimetics have been demonstrated in the fields of
therapeutics, diagnostics, and chemical biology. Strategies for the direct late-stage …

Highlights•Advances in transition-metal-mediated peptide modification and cyclization.•
Heteroatom coupling strategies facilitate Cys, Lys, and backbone N–H arylation.• …

Stapled peptides have been widely applied in many fields, including pharmaceutical
chemistry, diagnostic reagents, and materials science. However, most traditional stapled …

The late‐stage modification of structurally complex peptides bears great potential for drug
discovery, crop protection, and the pharmaceutical industry, among others. Whereas …

Bioorthogonal late‐stage diversification of structurally complex peptides has enormous
potential for drug discovery and molecular imaging. In recent years, transition‐metal …

The site‐selective chemical diversification of biomolecules constitutes an unmet challenge
of capital importance within medicinal chemistry and chemical biology. The functionalization …