Cell death has been divided into two main types: programmed cell death, in which the cell
plays an active role, and passive (necrotic) cell death. Senescence arrest, accelerated …

The first antitumor drug (aminopterin) was introduced into the treatment of childhood
leukemia by Sidney Farber almost 50 years ago. In the past 20 years long term remission …

The classical anti-cancer agents comprise cytotoxic compounds. Mostly, these drugs act by
exerting DNA damage. In essence, there are two major response phenotypes available to a …

Apoptosis and necrosis are two morphologically distinct forms of cell death that are
important for maintaining of cellular homeostasis. Almost all agents can provoke either …

Most of the cytotoxic anticancer drugs in current use have been shown to induce apoptosis
in susceptible cells. The fact that disparate agents, which interact with different targets …

Over the past two decades, the role of apoptosis in the cytotoxicity of anticancer drugs has
become clear. Apoptosis may occur via a death receptor‐dependent (extrinsic) or …

Antitumor therapy has expanded beyond the previous notions of cytotoxic or biologic
therapy to now include agents that induce differentiation (eg all trans-retinoic acid for …

INTRODUCTION: CELL DEATH AS AN ADAPTIVE RESPONSE TO DAMAGE IN TRYING to
understand why many cancer cells do not die after drug treatment, and are drug resistant, it …

Publisher Summary This chapter summarizes the actions and clinical uses of the three
classes of cancer chemotherapeutic agents—the DNA damaging agents, the …

Cancer cells that are sufficiently damaged by cancer chemotherapeutic agents (as well as
radiotherapy) eventually die in an ordered sequential biochemical process known as …