The majority of inherited retinal degenerative diseases and dry age-related macular
degeneration are characterized by decay of the outer retina and photoreceptors, which …

Retinal degenerative diseases are a leading cause of visual impairment or blindness. There
are many therapies for delaying the progression of vision loss but no curative strategies …

Retinal remodeling refers to a series of progressive pathological changes in the retina that
are caused by photoreceptor degeneration (Marc et al., 2003). This is (primarily) triggered by …

Mammalian retinal degenerations initiated by gene defects in rods, cones or the retinal
pigmented epithelium (RPE) often trigger loss of the sensory retina, effectively leaving the …

Photoreceptor degeneration caused by genetic defects leads to retinitis pigmentosa, a rare
disease typically diagnosed in adolescents and young adults. In most cases, rod loss occurs …

We studied the anatomical remodeling and gliosis of retinal Müller cells in the rd/rd mouse
model of photoreceptor degeneration. A computational calculation of glutamine synthetase …

Despite different aetiologies, most inherited retinal disorders culminate in photoreceptor
loss, which induces concomitant changes in the neural retina, one of the most striking being …

A striking aspect of tissue regeneration is its uneven distribution among different animal
classes, both in terms of modalities and efficiency. The retina does not escape the rule …

In contrast to mammals, zebrafish posses the remarkable ability to regenerate retinal
neurons. Damage to the zebrafish retina induces Müller glia to act as stem cells, generating …

Progressive and irreversible vision loss in mature and aging adults creates a health and
economic burden, worldwide. Despite the advancements of many contemporary therapies to …