A fine interplay exists between sensory experience and innate genetic programs leading to
the sculpting of neuronal circuits during early brain development. Recent evidence suggests …

The mammalian brain is plastic in the sense that it shows a remarkable capacity for change
throughout life. The contribution of neuronal activity to brain plasticity was first recognized in …

Modifications of neuronal circuits allow the brain to adapt and change with experience. This
plasticity manifests during development and throughout life, and can be remarkably long …

Adaptation to environmental changes is based on the perpetual generation of new
phenotypes. Modern biology has focused on the role of epigenetic mechanisms in …

Gene–environment interactions have long been recognized for their important role in
mediating the development and functions of the central nervous system (CNS). The study of …

Two major environmental developments have occurred in mammalian evolution which have
impacted on the genetic and epigenetic regulation of brain development. The first of these …

Brain development is a life-long process that encompasses several critical periods of
transition, during which significant cognitive changes occur. Embryonic development …

Neural stem/progenitor cells (NSCs/NPCs) give rise to neurons, astrocytes, and
oligodendrocytes. It has become apparent that intracellular epigenetic modification including …

A big part of the answer, scientists now think, is epigenetics—how nurture shapes nature.
Epigenetic mechanisms are molecular events that govern the way the environment …

OBJECTIVE: Child and adolescent psychiatry is rife with examples of the sustained effects of
early experience on brain function. The study of behavioral genetics provides evidence for a …