Acute lung injury (ALI), which is associated with a mortality of 30–40%, is attributable to
inflammation that develops rapidly across the lung's vast vascular surface, involving an …

Transmigration of neutrophils through the microvascular endothelium is a cardinal event of
acute inflammation. It has been suggested that gap junctions made of connexin43 (Cx43) …

Increased vascular permeability causes pulmonary edema that impairs arterial oxygenation
and thus contributes to morbidity and mortality associated with Acute Respiratory Distress …

Acid aspiration, a common cause of acute lung injury, leads to alveolar edema. Increase in
lung vascular permeability underlies this pathology. To define mechanisms, isolated rat …

Endothelial barrier restoration reverses microvessel hyperpermeability and facilitates
recovery from lung injury. Because inhibiting connexin 43 (Cx43)-dependent …

Transmigration of neutrophil polymorphonuclear leukocytes through the microvascular
endothelium is a cardinal event of acute inflammation. In vitro, this process can be restricted …

To assess the hypothesis that gap junctions (GJs) participate on leukocyte-endothelium
interactions in the inflammatory response, we compared leukocyte adhesion and …

Adhesion of circulating monocytes to vascular endothelial cells is a crucial event in
development of vascular inflammatory conditions, including atherosclerosis. We investigated …

Increased pulmonary vascular permeability is a hallmark of acute lung injury (ALI). Connexin
40 (Cx40) is a gap junctional protein abundantly present in the lung microvascular …

Macrophages are paracrine signalers that regulate tissular responses to injury through
interactions with parenchymal cells. Connexin hemichannels have recently been shown to …