Poor solubility is a major challenge that can limit the oral bioavailability of many drugs,
including delamanid, a weakly basic nitro-dihydro-imidazooxazole derivative used to treat …

Glass transition temperature (T g) is important for amorphous compounds because it can
have implications on their physical and chemical stability. With drugs that possess ionizable …

The development of amorphous solid dispersions (ASDs) is one way to overcome the
bioavailability challenges of poorly water-soluble active pharmaceutical ingredients (APIs) …

Enteric polymers are widely used in amorphous solid dispersion (ASD) formulations. The
aim of the current study was to explore ASD failure mechanisms across a wide range of pH …

We developed a step-by-step experimental protocol using differential scanning calorimetry
(DSC), dynamic vapour sorption (DVS), polarized light microscopy (PLM) and a small-scale …

Amorphous solid dispersions (ASDs) are commonly used to orally deliver small-molecule
drugs that are poorly water-soluble. ASDs consist of drug molecules in the amorphous form …

In this work, an amorphous solid dispersion (ASD) formulation was systematically developed
to simultaneously enhance bioavailability and mitigate the mechanical instability risk of the …

Robust and reliable in vivo performance of medicines based on amorphous solid
dispersions (ASDs) depend on maintenance of physical stability and efficient …

The formulation of oral amorphous solid dispersions (ASD) includes the use of excipients to
improve physical stability and enhance bioavailability. Combinations of excipients (polymers …

Amorphous solid dispersions (ASDs) can increase the oral bioavailability of poorly soluble
drugs. However, their use in drug development is comparably rare due to a lack of basic …