Cellular senescence is an irreversible cell arrest process, which is determined by a variety of
complicated mechanisms, including telomere attrition, mitochondrial dysfunction, metabolic …

Aging is a biological process characterized by a progressive functional decline in tissues
and organs, which eventually leads to mortality. Telomeres, the repetitive DNA repeat …

The aging process deteriorates organs' function at different levels, causing its progressive
decline to resist stress, damage, and disease. In addition to alterations in metabolic control …

Cellular senescence is the ultimate and irreversible loss of replicative capacity occurring in
primary somatic cell culture. It is triggered as a stereotypic response to unrepaired nuclear …

Mitochondrial functions and telomere functions have mostly been studied independently. In
recent years, it, however, has become clear that there are intimate links between …

Aging is an inevitable biological process that affects most living organisms. The process of
aging is regulated at the level of the organism, as well as at the level of tissues and cells …

Mitochondrial dysfunction and oxidative stress have been implicated in cellular senescence,
apoptosis, aging and aging‐associated pathologies. Telomere shortening and genomic …

Ageing organisms accumulate senescent cells that are thought to contribute to body
dysfunction. Telomere shortening and damage are recognized causes of cellular …

The accumulation of oxidative damage is one of the most widely accepted causes of ageing.
Mitochondrial dysfunction, in particular damage to the mitochondrial DNA has been …

Telomeres are protective structures present at the ends of linear chromosomes that are
important in preventing genome instability. Telomeres shorten as a result of cellular …