Progranulin (PGRN) is a soluble factor that regulates cell proliferation, motility and
inflammation. A role for PGRN in the progression of ovarian and breast cancers is well …

Progranulin (PGRN) is an autocrine growth factor and has important effects on regulation of
cell growth, motility, tissue repair and embryonic development. Recent years, several …

In previous years, progranulin (PGRN) has attracted increasing attention due to its
oncogenic roles in several types of tumor. However, the clinical relevance of PGRN in …

Progranulin (PGRN) has been shown to be involved in the process of inflammation, wound
healing, and cartilage development; and its role in the progression of breast and ovarian …

Progranulin (PGRN) is a secreted glycoprotein growth factor with tumorigenic roles in a
variety of tumors including, among others, breast, ovarian, prostate, bladder, and liver …

Progranulin (PGRN) mediates cell cycle progression and cell motility as a pleiotropic growth
factor and acts as a universal regulator of cell growth, migration and transformation, cell …

Cancer cells have defects in regulatory mechanisms that usually control cell proliferation
and homeostasis. Different cancer cells share crucial alterations in cell physiology, which …

Simple Summary The growth factor progranulin plays an important pro-tumorigenic role in
several solid tumors and a growing number of studies suggest diagnostic and prognostic …

The growth factor progranulin has emerged in recent years as a critical regulator of
transformation in several cancer models, including breast cancer, glioblastomas, leukemias …

Progranulin (PGRN) has been characterized as an autocrine growth and survival factor and
is known to stimulate tumorigenesis and proliferation of several types of cancer cell …