The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system
forms the major node of cellular and organismal defense against oxidative and electrophilic …

Transcription factor Nrf2 (NF-E2-related factor 2) is a master regulator of cellular responses
against environmental stresses. Nrf2 induces the expression of detoxification and …

The Keap1–Nrf2 regulatory system plays a central role in cytoprotection from electrophilic
and oxidative stress. In unstressed conditions, Nrf2 is constantly ubiquitinated by the Cul3 …

The Kelch-like ECH associated protein 1 (Keap1) is a component of a Cullin3-based Cullin-
RING E3 ubiquitin ligase (CRL) multisubunit protein complex. Within the CRL, homodimeric …

The kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2
(Nrf2) signaling axis serves as a “master regulator” in response to oxidative/electrophilic …

Redox imbalance and persistent inflammation are the underlying causes of most chronic
diseases. Mammalian cells have evolved elaborate mechanisms for restoring redox …

Abstract The Keap1-Nrf2 system plays pivotal roles in defense mechanisms by regulating
cellular redox homeostasis. Nrf2 is an inducible transcription factor that activates a battery of …

Summary The Keap1-Nrf2 system plays a central role in the oxidative stress response;
however, the identity of the reactive oxygen species sensor within Keap1 remains poorly …

Electrophile responsive element (EpRE)-mediated gene induction is a pivotal mechanism of
cellular defense against the toxicity of electrophiles and reactive oxygen species (ROS) …

Since eukaryotic cells constantly encounter various environmental insults, they have
evolved defense mechanisms to cope with toxicant-and carcinogen-induced oxidative stress …