DNA damage accumulation, defective chromatin organization and deficient DNA repair capacity in patients with rheumatoid arthritis
VL Souliotis, NI Vlachogiannis, M Pappa, A Argyriou… - Clinical …, 2019 - Elsevier
We investigated the DNA damage response and repair network in 18 patients with active
rheumatoid arthritis and tested the hypothesis that treatment influences this network. A 3-fold …
rheumatoid arthritis and tested the hypothesis that treatment influences this network. A 3-fold …
Increased DNA strand breaks in mononuclear cells from patients with rheumatoid arthritis.
LL Bhusate, KE Herbert, DL Scott… - Annals of the rheumatic …, 1992 - ard.bmj.com
Immune dysfunction is linked with lymphocyte DNA metabolism. In particular, DNA damage
may impair lymphocyte function and induce increased cell turnover; such changes are of …
may impair lymphocyte function and induce increased cell turnover; such changes are of …
Increased DNA damage and oxidative stress in patients with rheumatoid arthritis
O Altindag, M Karakoc, A Kocyigit, H Celik, N Soran - Clinical Biochemistry, 2007 - Elsevier
OBJECTIVES: Oxidative stress has been described as an important mechanism that
underlies chronic inflammation in rheumatoid arthritis (RA). The aim of the study was to …
underlies chronic inflammation in rheumatoid arthritis (RA). The aim of the study was to …
Increased sensitivity of PBMCs isolated from patients with rheumatoid arthritis to DNA damaging agents is connected with inefficient DNA repair
G Galita, O Brzezińska, I Gulbas, J Sarnik… - Journal of clinical …, 2020 - mdpi.com
Rheumatoid arthritis (RA) is a systemic, inflammatory disease of the joints and surrounding
tissues. RA manifests itself with severe joint pain, articular inflammation, and oxidative …
tissues. RA manifests itself with severe joint pain, articular inflammation, and oxidative …
Defective DNA repair and chromatin organization in patients with quiescent systemic lupus erythematosus
Background Excessive autoantibody production characterizing systemic lupus
erythematosus (SLE) occurs irrespective of the disease's clinical status and is linked to …
erythematosus (SLE) occurs irrespective of the disease's clinical status and is linked to …
A subset of patients with systemic lupus erythematosus fails to degrade DNA from multiple clinically relevant sources
J Leffler, K Ciacma, B Gullstrand, AA Bengtsson… - Arthritis Research & …, 2015 - Springer
Introduction Patients with systemic lupus erythematosus (SLE) have a decreased ability to
clear cell remnants and multiple deficiencies in the ability to degrade cellular chromatin …
clear cell remnants and multiple deficiencies in the ability to degrade cellular chromatin …
Oxidative DNA damage and cellular sensitivity to oxidative stress in human autoimmune diseases.
S Bashir, G Harris, MA Denman, DR Blake… - Annals of the …, 1993 - ard.bmj.com
OBJECTIVES--To estimate the extent of genomic DNA damage and killing of lymphocytes by
reactive oxygen intermediates in autoimmune diseases. METHODS--8-Oxo-7 …
reactive oxygen intermediates in autoimmune diseases. METHODS--8-Oxo-7 …
DNA Damage in Rheumatoid Arthritis: An Age‐Dependent Increase in the Lipid Peroxidation‐Derived DNA Adduct, Heptanone‐Etheno‐2′‐Deoxycytidine
M Ogawa, T Matsuda, A Ogata, T Hamasaki… - Autoimmune …, 2013 - Wiley Online Library
Objective. To evaluate what types of DNA damages are detected in rheumatoid arthritis
(RA). Methods. The DNA adducts such as 8‐oxo‐hydroxy‐7, 8‐dihydro‐2 …
(RA). Methods. The DNA adducts such as 8‐oxo‐hydroxy‐7, 8‐dihydro‐2 …
DNA-repair and mutations in immuncompetent cells from patients with rheumatic diseases and corresponding animal models
H Altmann - Stud. Biophys.;(German Democratic Republic), 1977 - osti.gov
Unscheduled DNA synthesis was investigated in lymphocytes of patients with different
inflammatory rheumatic diseases. After.. gamma.. irradiation H/sup 3/-thymidin incorporation …
inflammatory rheumatic diseases. After.. gamma.. irradiation H/sup 3/-thymidin incorporation …
Increased concentrations of antibody-bound circulatory cell-free DNA in rheumatoid arthritis
XY Zhong, I von Mühlenen, Y Li, A Kang… - Clinical …, 2007 - academic.oup.com
Background: Increased concentrations of cell-free DNA have been found in several
disorders and have been interpreted as evidence of increased rates of cell death or …
disorders and have been interpreted as evidence of increased rates of cell death or …
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