We investigated the DNA damage response and repair network in 18 patients with active
rheumatoid arthritis and tested the hypothesis that treatment influences this network. A 3-fold …

Immune dysfunction is linked with lymphocyte DNA metabolism. In particular, DNA damage
may impair lymphocyte function and induce increased cell turnover; such changes are of …

OBJECTIVES: Oxidative stress has been described as an important mechanism that
underlies chronic inflammation in rheumatoid arthritis (RA). The aim of the study was to …

Rheumatoid arthritis (RA) is a systemic, inflammatory disease of the joints and surrounding
tissues. RA manifests itself with severe joint pain, articular inflammation, and oxidative …

Background Excessive autoantibody production characterizing systemic lupus
erythematosus (SLE) occurs irrespective of the disease's clinical status and is linked to …

Introduction Patients with systemic lupus erythematosus (SLE) have a decreased ability to
clear cell remnants and multiple deficiencies in the ability to degrade cellular chromatin …

OBJECTIVES--To estimate the extent of genomic DNA damage and killing of lymphocytes by
reactive oxygen intermediates in autoimmune diseases. METHODS--8-Oxo-7 …

Objective. To evaluate what types of DNA damages are detected in rheumatoid arthritis
(RA). Methods. The DNA adducts such as 8‐oxo‐hydroxy‐7, 8‐dihydro‐2 …

Unscheduled DNA synthesis was investigated in lymphocytes of patients with different
inflammatory rheumatic diseases. After.. gamma.. irradiation H/sup 3/-thymidin incorporation …

Background: Increased concentrations of cell-free DNA have been found in several
disorders and have been interpreted as evidence of increased rates of cell death or …