The clinical relevance of gene expression based prognostic signatures in colorectal cancer

P Ahluwalia, R Kolhe, GK Gahlay - … et Biophysica Acta (BBA)-Reviews on …, 2021 - Elsevier
Colorectal cancer (CRC) is one of the most prevalent cancers, with more than one million
new cases every year. In the last few decades, several advancements in therapeutic and …

Clinical value of prognosis gene expression signatures in colorectal cancer: a systematic review

R Sanz-Pamplona, A Berenguer, D Cordero… - PloS one, 2012 - journals.plos.org
Introduction The traditional staging system is inadequate to identify those patients with stage
II colorectal cancer (CRC) at high risk of recurrence or with stage III CRC at low risk. A …

Survival marker genes of colorectal cancer derived from consistent transcriptomic profiling

J Martinez-Romero, S Bueno-Fortes, M Martín-Merino… - BMC genomics, 2018 - Springer
Background Identification of biomarkers associated with the prognosis of different cancer
subtypes is critical to achieve better therapeutic assistance. In colorectal cancer (CRC) the …

[HTML][HTML] A seven-gene signature predicts overall survival of patients with colorectal cancer

H Chen, X Sun, W Ge, Y Qian, R Bai, S Zheng - Oncotarget, 2017 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is a major cause of global cancer mortality. Gene expression
profiles can help predict prognosis of patients with CRC. In most of previous studies, disease …

Prognostic cancer gene expression signatures: current status and challenges

Y Qian, J Daza, T Itzel, J Betge, T Zhan, F Marmé… - Cells, 2021 - mdpi.com
Current staging systems of cancer are mainly based on the anatomical extent of disease.
They need refinement by biological parameters to improve stratification of patients for tumor …

Prognostic and predictive molecular biomarkers for colorectal cancer: updates and challenges

E Koncina, S Haan, S Rauh, E Letellier - Cancers, 2020 - mdpi.com
Colorectal cancer (CRC) is a leading cause of death among cancer patients. This
heterogeneous disease is characterized by alterations in multiple molecular pathways …

Predictive and prognostic markers in colorectal cancer

B George, S Kopetz - Current oncology reports, 2011 - Springer
Colorectal cancer (CRC) has a complex pathogenesis involving multiple sequential steps
with accumulation of genetic alterations including mutations, gene amplification, and …

Non‐invasive prognostic protein biomarker signatures associated with colorectal cancer

S Surinova, L Radová, M Choi, J Srovnal… - EMBO molecular …, 2015 - embopress.org
The current management of colorectal cancer (CRC) would greatly benefit from non‐
invasive prognostic biomarkers indicative of clinicopathological tumor characteristics. Here …

Prognostic gene expression signature associated with two molecularly distinct subtypes of colorectal cancer

SC Oh, YY Park, ES Park, JY Lim, SM Kim, SB Kim… - Gut, 2012 - gut.bmj.com
Aims Despite continual efforts to develop prognostic and predictive models of colorectal
cancer by using clinicopathological and genetic parameters, a clinical test that can …

Implementing prognostic and predictive biomarkers in CRC clinical trials

S Van Schaeybroeck, WL Allen… - Nature reviews Clinical …, 2011 - nature.com
Over the past two decades, several protein and genomic markers have refined the
prognostic information of colorectal cancer (CRC) and helped to predict which patient group …