Over the past 50 years, increasing experimental evidences have established that connexins
(Cxs) and gap junctional intercellular communication (GJIC) ensure an important role in both …

For decades, cancer was associated with gap-junction defects. However, more recently it
appeared that the gap junction proteins (connexins) could be re-expressed and participate …

Impaired expression of connexins, the gap junction subunits that facilitate direct cell-cell
communication, have been implicated in prostate cancer growth. To elucidate the crucial …

Prostate cancer is a prevalent disease that is characterized by a presumably long latency
period and a moderate propensity to metastasize. Although a range of mechanisms have …

BACKGROUND Connexins have their traditional function as part of gap junction (GJ)
structures, but have recently been shown to have GJ‐independent roles. Although GJs and …

Tissue homeostasis is the result of a complex intercellular network controlling the behavior
of every cell for the survival of the whole organism. In mammalian tissues, cells do …

The formation of aqueous intercellular channels mediating gap junctional intercellular
coupling (GJIC) is a canonical function of connexins (Cx). In contrast, mechanisms of GJIC …

The constituent proteins of gap junctions, called connexins (Cxs), have a short half-life.
Despite this, the physiological stimuli that control the assembly of Cxs into gap junctions and …

Despite research and clinical advances during recent decades, bone cancers remain a
leading cause of death worldwide. There is a low survival rate for patients with primary bone …

Gap junction-mediated communication is required for normal cellular growth and
differentiation. As cancer is thought to be a manifestation of the breakdown of cell-cell …