Adeno-associated virus (AAV) has shown promising therapeutic efficacy with a good safety
profile in a wide range of animal models and human clinical trials. With the advent of …

Adeno-associated viral (AAV) vectors packaging the CRISPR-Cas9 system (AAV-CRISPR)
can efficiently modify disease-relevant genes in somatic tissues with high efficiency. AAV …

CRISPR–Cas9 delivery by adeno-associated virus (AAV) holds promise for gene therapy
but faces critical barriers on account of its potential immunogenicity and limited payload …

The development of clustered regularly interspaced short-palindromic repeat (CRISPR)-
based biotechnologies has revolutionized the life sciences and introduced new therapeutic …

CRISPR/Cas9-based genome editing has quickly emerged as a powerful breakthrough
technology for use in diverse settings across biomedical research and therapeutic …

Owing to its easy-to-use and multiplexing nature, the genome editing tool CRISPR-Cas9
(clustered regularly interspaced short palindromic repeats (CRISPR) associated nuclease 9) …

CRISPR was first observed in 1987 in bacteria and archaea and was later confirmed as part
of bacterial adaptive immunity against the attacking phage. The CRISPR/Cas restriction …

In recent years, CRISPR (clustered regularly interspaced short palindromic repeat)/Cas
(CRISPR-associated) genome editing systems have become one of the most robust …

Conspectus The discovery of CRISPR/Cas has revolutionized the field of genome editing.
CRIPSR/Cas components are part of the bacterial immune system and are able to induce …

CRISPR/Cas9 is an effective gene editing tool with broad applications for the prevention or
treatment of numerous diseases. It depends on CRISPR (clustered regularly interspaced …