Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tb) and a few related
mycobacteria, is a devastating disease, killing more than a million individuals per year …

Clinical disease caused by the agent of tuberculosis, Mycobacterium tuberculosis, and by
less virulent mycobacteria, such as bacillus Calmette-Guérin (BCG) vaccines and …

Severe mycobacterial disease is mostly confined to patients who are immunocompromized
either by acquired or inherited causes. One such genetic disorder is Mendelian …

Tuberculosis (TB) is one of the most important causes of infectious morbidity and mortality
worldwide. Young children are more likely to develop severe disease from the causative …

Disseminated disease in children and pulmonary disease in adults constitute two major
epidemiological and clinical forms of tuberculosis. Paradoxically, only a small fraction of …

Worldwide, Mycobacterium tuberculosis causes more deaths than any other organism. It is
estmated that 1.7 billion people are infected with M. tuberculosis; the majority of those …

The pathogenesis of tuberculosis (TB) remains poorly understood, as no more than 5–10%
of individuals infected with Mycobacterium tuberculosis go on developing clinical disease …

In high burden settings, the risk of infection with Mycobacterium tuberculosis increases
throughout childhood due to cumulative exposure. However, the risk of progressing from …

Only a small fraction of individuals exposed to Mycobacterium tuberculosis develop clinical
tuberculosis (TB). Over the past century, epidemiological studies have shown that human …

One of the challenges faced by the infant immune system is learning to distinguish the
myriad of foreign but nonthreatening antigens encountered from those expressed by true …