Purpose Prophylactic surgery is a preemptive strategy for hereditary breast and ovarian
cancer (HBOC). Prophylactic mastectomy (PM) reduces breast cancer risk by> 90%. The aim …

Background BRCA1/2 mutation carriers and women from a hereditary breast (/ovarian)
cancer family have a highly increased risk of developing breast cancer (BC). Prophylactic …

Background This study sought to determine the likelihood of occult malignancy during risk-
reducing mastectomy in high-penetrance pathogenic variant carriers to help refine axillary …

Background: Preoperative genetic testing affects the surgical decision-making among
women with breast cancer. To avoid breast-conserving surgery and to offer the possibility of …

Background Women with a BRCA mutation have significantly elevated breast cancer risk,
which can be reduced by> 90% with bilateral prophylactic mastectomy (BPM). We sought to …

Background: Female breast cancer patients with a BRCA1/2 mutation have an increased
risk of contralateral breast cancer. We investigated the effect of rapid genetic counselling …

Prophylactic mastectomy (PM) is a risk‐management option for women at high familial risk of
breast cancer (BC). This study describes the PM experience of women enrolled in a large …

Aim: Women with a proven BRCA1 or BRCA2 germ-line mutation or with a 50% risk of
carrying the mutation, have an increased risk of breast cancer. Regular surveillance …

Aim: To examine the outcome of prophylactic mastectomy in a hospital-based series of
BRCA1/2 gene mutation carriers with and without a history of breast cancer. Patients and …

Purpose: Women with a hereditary predisposition for breast cancer have an extremely high
risk of developing invasive breast carcinoma, and many women consider prophylactic …