High rate of occult cancer found in prophylactic mastectomy specimens despite thorough presurgical assessment with MRI and ultrasound: findings from the …

H Yamauchi, M Okawa, S Yokoyama… - Breast Cancer Research …, 2018 - Springer
Purpose Prophylactic surgery is a preemptive strategy for hereditary breast and ovarian
cancer (HBOC). Prophylactic mastectomy (PM) reduces breast cancer risk by> 90%. The aim …

Factors influencing prophylactic surgical intervention in women with genetic predisposition for breast cancer

P Humar, Z Balogun, N Douglas… - Journal of Surgical …, 2024 - Wiley Online Library
Abstract Introduction In the United States, 5%–10% of breast cancer cases are due to
genetic predisposition. Among this population, prophylactic mastectomy is viable risk …

Prophylactic mastectomy in BRCA1/2 mutation carriers and women at risk of hereditary breast cancer: long-term experiences at the Rotterdam Family Cancer Clinic

BAM Heemskerk-Gerritsen, CTM Brekelmans… - Annals of surgical …, 2007 - Springer
Background BRCA1/2 mutation carriers and women from a hereditary breast (/ovarian)
cancer family have a highly increased risk of developing breast cancer (BC). Prophylactic …

Incidence of Occult Breast Cancer in Carriers of BRCA1/2 or Other High-Penetrance Pathogenic Variants Undergoing Prophylactic Mastectomy: When is Sentinel …

SM Wong, A Ferroum, C Apostolova… - Annals of Surgical …, 2022 - Springer
Background This study sought to determine the likelihood of occult malignancy during risk-
reducing mastectomy in high-penetrance pathogenic variant carriers to help refine axillary …

Impact of genetic counseling on the uptake of contralateral prophylactic mastectomy among younger women with breast cancer

T Terkelsen, H Rønning, AB Skytte - Acta Oncologica, 2020 - Taylor & Francis
Background: Preoperative genetic testing affects the surgical decision-making among
women with breast cancer. To avoid breast-conserving surgery and to offer the possibility of …

Differences among a modern cohort of BRCA mutation carriers choosing bilateral prophylactic mastectomies compared to breast surveillance

E Gilbert, EC Zabor, M Stempel, D Mangino… - Annals of surgical …, 2017 - Springer
Background Women with a BRCA mutation have significantly elevated breast cancer risk,
which can be reduced by> 90% with bilateral prophylactic mastectomy (BPM). We sought to …

Impact of rapid genetic counselling and testing on the decision to undergo immediate or delayed prophylactic mastectomy in newly diagnosed breast cancer patients …

MR Wevers, NK Aaronson, S Verhoef… - British journal of …, 2014 - nature.com
Background: Female breast cancer patients with a BRCA1/2 mutation have an increased
risk of contralateral breast cancer. We investigated the effect of rapid genetic counselling …

Clinical, pathological and genetic features of women at high familial risk of breast cancer undergoing prophylactic mastectomy

C Scott, DG Iorgulescu, HJ Thorne… - Clinical …, 2003 - Wiley Online Library
Prophylactic mastectomy (PM) is a risk‐management option for women at high familial risk of
breast cancer (BC). This study describes the PM experience of women enrolled in a large …

Clinical experience of prophylactic mastectomy followed by immediate breast reconstruction in women at hereditary risk of breast cancer (HB (O) C) or a proven …

CME Contant, MBE Menke-Pluijmers… - European Journal of …, 2002 - Elsevier
Aim: Women with a proven BRCA1 or BRCA2 germ-line mutation or with a 50% risk of
carrying the mutation, have an increased risk of breast cancer. Regular surveillance …

Prophylactic mastectomy in BRCA1 and BRCA2 mutation carriers: very low risk for subsequent breast cancer

R Kaas, S Verhoef, J Wesseling, MA Rookus… - Annals of …, 2010 - journals.lww.com
Aim: To examine the outcome of prophylactic mastectomy in a hospital-based series of
BRCA1/2 gene mutation carriers with and without a history of breast cancer. Patients and …