Sowing malignant cells (the “seeds” of metastasis) to engraft secondary sites requires a
conducive premetastatic niche (PMN, the “soil” of metastasis). Inflammation and tumor …

Cancer metastasis is the leading cause of cancer-related deaths. The indispensable role of
platelets in tumor metastasis inspires the targeted delivery strategy by using platelet-drug …

The tumor microenvironment maintains a sufficient immunosuppressive state owing to the
existence of the immunosuppressive factors. The most prominent such factor is transforming …

Poor targeting of therapeutics leading to severe adverse effects on normal tissues is
considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug …

Various targeting strategies and ligands have been employed to direct nanoparticles to
tumors that upregulate specific cell-surface molecules. However, tumors display a dynamic …

Theranostic nanoparticles recently received great interest for uniting unique functions to
amplify therapeutic efficacy and reduce side effects. Despite the enhanced permeability and …

Activated platelets can maintain tumor vessel integrity, thereby leading to limited tumor
perfusion and suboptimal antitumor efficacy of nanoparticle-based drugs. Herein, to disrupt …

Nanomedicine is revolutionizing the treatment of cancer and has achieved unprecedented
outcomes over the past decades. The accumulation of Nanoparticles (NPs) in different …

Disseminated tumors are poorly accessible to nanoscale drug delivery systems because of
the vascular barrier, which attenuates extravasation at the tumor site. We investigated P …

In recent years, tremendous advancements in nanomedicine have resulted in the rapid
development of various nanoformulations, especially the treatment of solid tumors. Despite …