Accurate prediction of TCR-pMHC binding is important for the development of cancer
immunotherapies, especially TCR-based agents. Existing algorithms often experience …

Neoantigens play a key role in the recognition of tumour cells by T cells; however, only a
small proportion of neoantigens truly elicit T-cell responses, and few clues exist as to which …

T cells have the ability to eliminate infected and cancer cells and play an essential role in
cancer immunotherapy. T cell activation is elicited by the binding of the T cell receptor (TCR) …

Motivation T cells play an essential role in adaptive immune system to fight pathogens and
cancer but may also give rise to autoimmune diseases. The recognition of a peptide–MHC …

Understanding the recognition of specific epitopes by cytotoxic T cells is a central problem in
immunology. Although predicting binding between peptides and the class I Major …

The identification of T cell neo-epitopes is fundamental and computational challenging in
tumor immunotherapy study. As the binding of pMHC-T cell receptor (TCR) is the essential …

Computational modelling of the interactions between T-cell receptors (TCRs) and epitopes
is of great importance for immunotherapy and antigen discovery. However, current TCR …

T-cell receptors (TCRs) on T cells recognize and bind to epitopes presented by the major
histocompatibility complex in case of an infection or cancer. However, the high diversity of …

The recognition of T‐cell receptor (TCR) on the surface of T cell to specific epitope
presented by the major histocompatibility complex is the key to trigger the immune response …

T cells are crucial players of immune responses by their ability to specifically recognize
foreign, potentially harmful, antigens. To perform such specific recognition, T cells express at …