The chronic mild stress (CMS) paradigm was developed in order to simulate in animals the
symptom of anhedonia, a major feature of depression. Typically, changes in hedonic status …

Anhedonia, a core symptom of clinical depression, refers to the loss of interest in normally
rewarding stimuli; the chronic mild stress paradigm, an animal model of depression, was …

The chronic mild stress (CMS) paradigm was developed to model anhedonia in animals.
The repeated administration of a series of unpredictable, mild stressors attempts to mimic …

Many symptoms of human depressive disorders are also observed in animals after exposure
to unpredictable stressors. The chronic mild stress (CMS) paradigm was developed in order …

Chronic exposure to mild unpredictable stress (CMS) has previously been found to
decrease hedonic responsiveness, as measured by the consumption of palatable sweet …

The chronic mild stress (CMS) procedure was developed in rodents to target anhedonia, the
core symptom of depressive melancholia. Stress exposure has been shown to induce a …

Background In a substantial proportion of depressed patients, stressful life events play a role
in triggering the evolution of the illness. Exposure to stress has effects on different levels in …

The chronic unpredictable mild stress (CMS) is a paradigm developed in animals to model
the relatively minor and unanticipated irritants that lead to a state of anhedonia in some …

Chronic exposure to mild unpredictable stress (CMS) has previously been found to depress
the consumption of a weak (1%) sucrose solution by rats. This effect was confirmed in each …

Sex differences in behavioral and neurobiological responses to stress are considered to
modulate the prevalence of some psychiatric disorders, including major depression. In the …