Moving Beyond Isothiocyanates: A Look at the Stability of Conjugation Links Toward Radiolysis in 89Zr-Labeled Immunoconjugates
R Vizier, P Adumeau, M Moreau… - Bioconjugate …, 2024 - ACS Publications
Zirconium-89 is the most widely used radioisotope for immunoPET because its physical half-
life (78.2 h) suits the one of antibodies. Desferrioxamine B (DFO) is the standard chelator for …
life (78.2 h) suits the one of antibodies. Desferrioxamine B (DFO) is the standard chelator for …
[HTML][HTML] p-Isothiocyanatobenzyl-desferrioxamine: a new bifunctional chelate for facile radiolabeling of monoclonal antibodies with zirconium-89 for immuno-PET …
LR Perk, MJWD Vosjan, GWM Visser, M Budde… - European journal of …, 2010 - Springer
Purpose Immuno-PET is an emerging imaging tool for the selection of high potential
antibodies (mAbs) for imaging and therapy. The positron emitter zirconium-89 (89 Zr) has …
antibodies (mAbs) for imaging and therapy. The positron emitter zirconium-89 (89 Zr) has …
Comparison of 64Cu-Complexing Bifunctional Chelators for Radioimmunoconjugation: Labeling Efficiency, Specific Activity, and in Vitro/in Vivo Stability
MS Cooper, MT Ma, K Sunassee, KP Shaw… - Bioconjugate …, 2012 - ACS Publications
High radiolabeling efficiency, preferably to high specific activity, and good stability of the
radioimmunoconjugate are essential features for a successful immunoconjugate for imaging …
radioimmunoconjugate are essential features for a successful immunoconjugate for imaging …
[HTML][HTML] The race for hydroxamate-based zirconium-89 chelators
IVJ Feiner, M Brandt, J Cowell, T Demuth, D Vugts… - Cancers, 2021 - mdpi.com
Simple Summary Chelators are small molecules that can form a complex with a metal ion by
coordinating electron rich atoms from the chelator to the electron-poor cation …
coordinating electron rich atoms from the chelator to the electron-poor cation …
Combining Desferriferrioxamine B and 1‐Hydroxy‐2‐Piperidone ((PIPO)H) to Chelate Zirconium. Solution Structure of a Model Complex of the [89Zr]Zr−DFOcyclo …
F Mangin, O Fonquernie, P Jewula, S Brandès… - …, 2024 - Wiley Online Library
Abstract 89Zr− immunoPET is a hot topic as 89Zr cumulates the advantages of 64Cu and
124I without their drawbacks. We report the synthesis of a model ligand of a chiral …
124I without their drawbacks. We report the synthesis of a model ligand of a chiral …
Multifunctional Desferrichrome Analogues as Versatile 89Zr(IV) Chelators for ImmunoPET Probe Development
New bifunctional hexa-and octadentate analogues of the hydroxamate-containing
siderophore desferrichrome (DFC) have been synthesized and evaluated as 89Zr-chelating …
siderophore desferrichrome (DFC) have been synthesized and evaluated as 89Zr-chelating …
Stability of a metabolizable ester bond in radioimmunoconjugates
Y Arano, K Wakisaka, T Mukai, T Uezono… - Nuclear medicine and …, 1996 - Elsevier
Ester bonds have been used as metabolizable linkages to reduce radioactivity levels in non-
target tissues following the administration of antibodies labeled with metallic radionuclides …
target tissues following the administration of antibodies labeled with metallic radionuclides …
[HTML][HTML] Direct comparison of the in vitro and in vivo stability of DFO, DFO* and DFOcyclo* for 89Zr-immunoPET
R Raavé, G Sandker, P Adumeau, CB Jacobsen… - European Journal of …, 2019 - Springer
Purpose Currently, the most commonly used chelator for labelling antibodies with 89 Zr for
immunoPET is desferrioxamine B (DFO). However, preclinical studies have shown that the …
immunoPET is desferrioxamine B (DFO). However, preclinical studies have shown that the …
[HTML][HTML] Comparison of the octadentate bifunctional chelator DFO*-pPhe-NCS and the clinically used hexadentate bifunctional chelator DFO-pPhe-NCS for 89Zr …
DJ Vugts, C Klaver, C Sewing, AJ Poot… - European journal of …, 2017 - Springer
Abstract Purpose All clinical 89 Zr-immuno-PET studies are currently performed with the
chelator desferrioxamine (DFO). This chelator provides hexadentate coordination to …
chelator desferrioxamine (DFO). This chelator provides hexadentate coordination to …
New Bifunctional Chelators Incorporating Dibromomaleimide Groups for Radiolabeling of Antibodies with Positron Emission Tomography Imaging Radioisotopes
M Farleigh, TT Pham, Z Yu, J Kim… - Bioconjugate …, 2021 - ACS Publications
Positron Emission Tomography (PET) imaging with antibody-based contrast agents
frequently uses the radioisotopes [64Cu] Cu2+ and [89Zr] Zr4+. The macrobicyclic chelator …
frequently uses the radioisotopes [64Cu] Cu2+ and [89Zr] Zr4+. The macrobicyclic chelator …