By catalyzing hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine
monophosphate (cGMP), cyclic nucleotide phosphodiesterases are critical regulators of their …

Cyclic adenosine 3'5'-monophosphate (cAMP) and cyclic guanosine 3'5'-monophoshpate
(cGMP) are critical intracellular second-messengers involved in the transduction of a wide …

Cyclic nucleotide phosphodiesterases (PDEs), which are ubiquitously distributed in
mammalian tissues, play a major role in cell signaling by hydrolyzing cAMP and cGMP. Due …

Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that regulate the cellular levels
of the second messengers, cAMP and cGMP, by controlling their rates of degradation. There …

The superfamily of cyclic nucleotide (cN) phosphodiesterases (PDEs) is comprised of 11
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …

Cyclic nucleotide phosphodiesterases (PDEs) are superfamily of enzymes that regulate the
spatial and temporal relationship of second messenger signaling in the cellular system …

Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolysis of cyclic AMP and
cyclic GMP, thereby regulating the intracellular concentrations of these cyclic nucleotides …

Cyclic nucleotide phosphodiesterases (PDEs) that specifically inactivate the intracellular
messengers cAMP and cGMP in a compartmentalized manner represent an important …

The establishment of a Gordon Research Conference devoted to cyclic nucleotide
phosphodiesterases has had an enormous impact on the field by facilitating collaborations …

Publisher Summary The intracellular levels of cyclic nucleotides are regulated through
synthesis by adenylyl and guanylyl cyclases and also degradation by phosphodiesterases …