Intense research in recent years has shown that many pre-mRNA processing events are co-
transcriptional or at least begin during RNA synthesis by RNA polymerase II (Pol II). But is it …

Interaction between transcription and pre-mRNA processing via binding of polymerase II
(Pol II) to factors involved in capping, splicing, and polyadenylation has recently been …

There is an emerging consensus that RNA polymerase II (RNA Pol II) transcription and pre-
mRNA processing are tightly coupled events. We show here that exons flanking an intron …

Transcription and pre-mRNA splicing are extremely complex multimolecular processes that
involve protein–DNA, protein–RNA, and protein–protein interactions. Splicing occurs in the …

RNA processing is carried out in close proximity to the site of transcription, suggesting a
regulatory link between transcription and pre-mRNA splicing. Using an in vitro …

Eukaryotic cells must execute a complex program to scripts engineered to be synthesized by
RNA polymergenerate mature functional messenger RNA (mRNA). ase III in mammalian …

Capping, splicing, and cleavage/polyadenylation of pre-mRNAs are interdependent events
that are all stimulated in vivo by the carboxy-terminal domain (CTD) of RNA Pol II. We show …

Biochemical evidence indicates that pre-mRNA splicing factors physically interact with the C-
terminal domain of the largest subunit of RNA polymerase II. We have investigated the in …

We investigated the role of RNA polymerase II (pol II) carboxy-terminal domain (CTD)
phosphorylation in pre-mRNA processing coupled and uncoupled from transcription in …

While studies of alternative pre-mRNA splicing regulation have typically focused on RNA-
binding proteins and their target sequences within nascent message, it is becoming …