Aims/hypothesis: We examined the pancreatic islet lesions in Japanese patients with Type II
diabetes mellitus to determine if the damage was related to oxidative stress. Methods …

OBJECTIVE Deficits of β-cells characterize the islet pathology in type 2 diabetes. It is yet to
be clear how the β-cell loss develops in type 2 diabetes. We explored the implication of …

Oxidative stress is produced under diabetic conditions and is likely involved in progression
of pancreatic β-cell dysfunction found in diabetes. Possibly caused by low levels of …

To shed further light on the primary alterations of insulin secretion in type 2 diabetes and the
possible mechanisms involved, we studied several functional and molecular properties of …

Several properties of pancreatic β-cells in type 2 diabetes (T2D) were studied by using islets
isolated from T2D subjects. Moreover, because metformin has protective effects on …

Aims/hypothesis. Prolonged poor glycaemic control in patients with Type II (non-insulin-
dependent) diabetes mellitus often causes pancreatic beta-cell dysfunction accompanied by …

2. We therefore investigated the lipid peroxide level (thiobarbituric acid-reactive substances,
TBARS) and activities of antioxidant enzymes [superoxide dismutase (SOD), catalase and …

Aims/hypothesis Islet amyloid in type 2 diabetes contributes to loss of beta cell mass and
function. Since islets are susceptible to oxidative stress-induced toxicity, we sought to …

Aims/hypothesis Pancreatic beta cells have highly developed endoplasmic reticulum (ER)
due to their role in insulin secretion. Since ER stress has been associated with beta cell …

Oxidative stress is produced under diabetic conditions and possibly causes various forms of
tissue damage in patients with diabetes. The aim of this study was to examine the …