A geroscience-informed approach to the increasing prevalence of bladder control problems
in older adults requires understanding the impact of aging on dynamic mechanisms that …

The Hyperpolarization activated, cyclic nucleotide gated (HCN) channel is a candidate
mediator of neuroendocrine influence over detrusor tonus during filling. In other tissues …

Objective To assess the functional role of Hyperpolarization-activated cyclic nucleotide-
gated gated channel (HCN) subtypes in the aging bladder phenotype characterized by …

Control of urinary continence is predicated on sensory signaling about bladder volume.
Bladder sensory nerve activity is dependent on tension, implicating autonomic control over …

Purpose: Hyperpolarization-activated cyclic nucleotide gated non-selective (HCN) channels
have been demonstrated in the urinary bladder in various species. Since they play a major …

Volume hyposensitivity resulting from impaired sympathetic detrusor relaxation during
bladder filling contributes to detrusor underactivity (DU) associated with aging. Detrusor …

Key points The prevalence of bladder conditions such as overactive bladder syndrome and
urinary incontinence significantly increases with age, but how bladder function is altered by …

Aims To evaluate the functional and molecular alterations of contractile and relaxant
machinery in the bladder and urethra that lead to the underactive bladder (UAB) in old …

Ageing is associated with deteriorating urinary bladder function and an increasing
prevalence of disorders such as underactive bladder. There are suggestions that G protein …

Control of urinary continence is predicated on sensory signaling about bladder volume.
Bladder sensory nerve activity is dependent on tension, implicating autonomic control over …