Oligodendrogliomas are brain tumors accounting for approximately 10% of all central
nervous system cancers. CIC is a transcription factor that is mutated in most patients with …

Inactivating mutations in the transcriptional repression factor Capicua (CIC) occur in
approximately 50% of human oligodendrogliomas, but mechanistic links to pathogenesis …

Capicua (CIC) is a transcriptional repressor that counteracts activation of genes downstream
of receptor tyrosine kinase (RTK)/Ras/ERK signaling. It is well-established that …

Capicua (Cic) is a transcriptional repressor mutated in the brain cancer oligodendroglioma.
Despite its cancer link, little is known of Cic's function in the brain. We show that nuclear Cic …

Capicua, encoded by the gene CIC, is an evolutionarily conserved high‐mobility group‐box
transcription factor downstream of the receptor tyrosine kinase and mitogen‐activated …

Capicua (CIC), a member of the high mobility group–box (HMG-box) superfamily of
transcriptional repressors, is frequently mutated in human oligodendrogliomas. However, its …

Gliomas are the most prevalent neurological cancer in the USA and care modalities are not
able to effectively combat these aggressive malignancies. Identifying new, more effective …

High-constitutive activity of the DNA damage response protein checkpoint kinase 1 (CHK1)
has been shown in glioblastoma (GBM) cell lines and in tissue sections. However, whether …

Mutations affecting the RAS–MAPK pathway frequently occur in relapsed neuroblastoma
tumors, which suggests that activation of this pathway is associated with a more aggressive …

CIC encodes a transcriptional repressor, capicua (CIC), whose disrupted activity appears to
be involved in several cancer types, including type I low‐grade gliomas (LGGs) and stomach …