[HTML][HTML] The impact of crystal phase transition on the hardness and structure of kidney stones

U Michibata, M Maruyama, Y Tanaka, M Yoshimura… - Urolithiasis, 2024 - Springer
Calcium oxalate kidney stones, the most prevalent type of kidney stones, undergo a multi-
step process of crystal nucleation, growth, aggregation, and secondary transition. The …

Unveiling Harmful Phase Transition of Kidney Stones and its Clinical Impact

M Maruyama, U Michibata, Y Tanaka, M Yoshimura… - 2023 - researchsquare.com
Calcium oxalate kidney stones, the most prevalent type of kidney stones, undergo a multi-
step process of crystal nucleation, growth, aggregation, and secondary transition. The …

Evidence for solution-mediated phase transitions in kidney stones: Phase Transition exacerbates kidney Stone Disease

M Maruyama, Y Tanaka, K Momma… - Crystal Growth & …, 2023 - ACS Publications
In this study, we investigated calcium oxalate (CaOx) kidney stones and showed direct
evidence of the solution-mediated phase transition of calcium oxalate dihydrate (COD; the …

Calcium phosphate controls nucleation and growth of calcium oxalate crystal phases in kidney stones

U Michibata, M Maruyama, Y Tanaka… - Biomedical …, 2024 - jstage.jst.go.jp
Kidney stone disease is a serious disease due to the severe pain it causes, high morbidity,
and high recurrence rate. Notably, calcium oxalate stones are the most common type of …

[HTML][HTML] Dual roles of brushite crystals in calcium oxalate crystallization provide physicochemical mechanisms underlying renal stone formation

R Tang, GH Nancollas, JL Giocondi, JR Hoyer… - Kidney international, 2006 - Elsevier
Calcium oxalate monohydrate (COM) crystals are the major mineral component of most
kidney stones, and thus have an important role in chronic human disease. However, the …

[HTML][HTML] Systematic evaluation for effects of urine pH on calcium oxalate crystallization, crystal-cell adhesion and internalization into renal tubular cells

J Manissorn, K Fong-Ngern, P Peerapen… - Scientific reports, 2017 - nature.com
Urine pH has been thought to be an important factor that can modulate kidney stone
formation. Nevertheless, there was no systematic evaluation of such pH effect. Our present …

[HTML][HTML] Quantitative analysis of calcium oxalate monohydrate and dihydrate for elucidating the formation mechanism of calcium oxalate kidney stones

M Maruyama, KP Sawada, Y Tanaka, A Okada… - PLoS …, 2023 - journals.plos.org
We sought to identify and quantitatively analyze calcium oxalate (CaOx) kidney stones on
the order of micrometers, with a focus on the quantitative identification of calcium oxalate …

Aggregation of calcium phosphate and oxalate phases in the formation of renal stones

B Xie, TJ Halter, BM Borah… - Crystal growth & design, 2015 - ACS Publications
The majority of human kidney stones are comprised of multiple calcium oxalate
monohydrate (COM) crystals encasing a calcium phosphate nucleus. The physiochemical …

Mp05-07 validating the theory of phase transition from calcium oxalate dihydrate to monohydrate in the stone formation: the first artificial in vivo experiment

M Maruyama, U Michibata, Y Tanaka… - The Journal of …, 2023 - auajournals.org
INTRODUCTION AND OBJECTIVE: We have previously reported that the phase transition
phenomenon of calcium oxalate (CaOx) makes urinary stones harder. Knowing phase …

Pathological biomineralization of kidney stones

JA Wesson, MD Ward - Elements, 2007 - pubs.geoscienceworld.org
Kidney stones are aggregates of microcrystals, most commonly containing calcium oxalate
monohydrate (COM) as the primary constituent. The formation of these aggregates in the …