Cardiovascular disease (CVD) causes an unparalleled proportion of the global burden of
disease and will remain the main cause of mortality for the near future. Oxidative stress plays …

Extensive epidemiological evidence and animal experimental studies suggest that
cruciferous vegetables may prevent or delay various inflammatory disorders, including …

Diabetes and cardiometabolic disorders such as hypertension and obesity are major risk
factors for the development of cardiovascular disease, with a wealth of evidence suggesting …

Current opinions with respect to the etiology of chronic diseases such as neurodegenerative
disease, cardiovascular diseases, and cancer are still controversial. There are multiple …

Cruciferous vegetables hold a myriad of bioactive molecules that are renowned for
possessing unique medicinal benefits. Sulforaphane (SFN) is one of the potential …

In this paper, we review recent evidence about the beneficial effects of sulforaphane (SFN),
which is the most studied member of isothiocyanates, on both in vivo and in vitro models of …

Cardiotoxicity is one of the major side effects encountered during cancer chemotherapy with
doxorubicin (DOX) and other anthracyclines. Previous studies have shown that oxidative …

The NFE2L2 gene encodes the transcription factor Nrf2 best known for regulating the
expression of antioxidant and detoxification genes. Gene knockout approaches have …

The isothiocyanate sulforaphane (SF), abundant in Cruciferous vegetables, is known to
induce antioxidant/detoxification enzymes in many cancer cell lines, but studies focused on …

The consumption of cruciferous vegetables has long been associated with a reduced risk in
the occurrence of cancer at various sites, including the prostate, lung, breast and colon. This …