Estrogen signaling modulates allergic inflammation and contributes to sex differences in asthma

A Keselman, N Heller - Frontiers in immunology, 2015 - frontiersin.org
Asthma is a chronic airway inflammatory disease that affects~ 300 million people worldwide.
It is characterized by airway constriction that leads to wheezing, coughing, and shortness of …

Mechanisms driving gender differences in asthma

H Fuseini, DC Newcomb - Current allergy and asthma reports, 2017 - Springer
Abstract Purpose of Review Many phenotypes of asthma exist, ranging from mild asthma
with onset during childhood to severe asthma with later onset, making asthma a broad …

Steady-state estradiol triggers a unique innate immune response to allergen resulting in increased airway resistance

KJ Warren, C Deering-Rice, T Huecksteadt… - Biology of sex …, 2023 - Springer
Rationale Asthma is a chronic airway condition that occurs more often in women than men
during reproductive years. Population studies have collectively shown that long-term use of …

Hormones, sex, and asthma

JA Yung, H Fuseini, DC Newcomb - Annals of Allergy, Asthma & …, 2018 - Elsevier
Objective To summarize the current literature on the sex disparity in asthma and the role of
sex hormone signaling in allergic and neutrophilic airway inflammation. Data Sources …

Sex steroids effects on asthma: a network perspective of immune and airway cells

NA Borkar, CK Combs, V Sathish - Cells, 2022 - mdpi.com
A multitude of evidence has suggested the differential incidence, prevalence and severity of
asthma between males and females. A compilation of recent literature recognized sex …

Asthma is different in women

JG Zein, SC Erzurum - Current allergy and asthma reports, 2015 - Springer
Gender differences in asthma incidence, prevalence and severity have been reported
worldwide. After puberty, asthma becomes more prevalent and severe in women, and is …

Role of estrogen receptors α and β in a murine model of asthma: exacerbated airway hyperresponsiveness and remodeling in ERβ knockout mice

RSR Kalidhindi, NS Ambhore, S Bhallamudi… - Frontiers in …, 2020 - frontiersin.org
Epidemiological data suggests increased prevalence of asthma in females than males,
suggesting a plausible role for sex-steroids, especially estrogen in the lungs. Estrogen …

The impact of estrogen and progesterone on asthma

CL Haggerty, RB Ness, S Kelsey… - Annals of Allergy, Asthma & …, 2003 - Elsevier
OBJECTIVE: This paper describes evidence of a positive effect of both endogenous and
exogenous estrogen and progesterone on lung function across the life span in women …

Sex bias in asthma prevalence and pathogenesis

R Shah, DC Newcomb - Frontiers in immunology, 2018 - frontiersin.org
Sex-related differences in asthma prevalence are well established and change through the
reproductive phases of life. As children, boys have increased prevalence of asthma …

Estradiol activates mast cells via a non-genomic estrogen receptor-α and calcium influx

M Zaitsu, SI Narita, KC Lambert, JJ Grady… - Molecular …, 2007 - Elsevier
BACKGROUND: Allergic airway diseases are more common in females than in males during
early adulthood. A relationship between female hormones and asthma prevalence and …