Unnatural helical peptidic foldamers have attracted considerable attention owing to their
unique folding behaviours, diverse artificial protein binding mechanisms, and promising …

Conspectus Foldamers have defined and predictable structures, improved resistance to
proteolytic degradation, enhanced chemical diversity, and are versatile in their mimicry of …

New types of foldamer scaffolds are formidably challenging to design and synthesize, yet
highly desirable as structural mimics of peptides/proteins with a wide repertoire of functions …

Folded polymers are utilized in virtually all vital processes in nature. Non-natural folded
polymers (foldamers) have the potential for being similarly or even more versatile, and the …

The continued expansion of the fields of macromolecular chemistry and nanoscience has
motivated the development of new secondary structures that can serve as architectural …

Highlights•Peptidic foldamers can display improved properties over natural peptides in
vivo.•Designed d-peptides and α/β-peptides can target irregularly-shaped protein …

Conspectus The prospect of recreating the complex structural hierarchy of protein folding in
synthetic oligomers with backbones that are artificial in covalent structure (“foldamers”) has …

This note describes the design, synthesis, and conformational studies of a novel hybrid
foldamer that adopts a definite compact, three-dimensional structure determined by a …

Non-natural folded polymers (foldamers) display considerable versatility, and the design of
such molecules is of great current interest. In this respect, peptidic foldamers are perhaps …

Introduction: Proteins and other biologics comprise emerging therapeutic class with
efficacies against targets for which development of small-molecule antagonists has been …