Growth hormone action in somatostatin neurons regulates anxiety and fear memory

WO Dos Santos, VAL Juliano, FM Chaves… - Journal of …, 2023 - Soc Neuroscience
Dysfunctions in growth hormone (GH) secretion increase the prevalence of anxiety and
other neuropsychiatric diseases. GH receptor (GHR) signaling in the amygdala has been …

Effects of disrupted ghrelin receptor function on fear processing, anxiety and saccharin preference in mice

A Pierre, Y Regin, A Van Schuerbeek, EM Fritz… - …, 2019 - Elsevier
Background Obesity is a risk factor for stress-related mental disorders such as post-traumatic
stress disorder. The underlying mechanism through which obesity affects mental health …

Desacyl ghrelin decreases anxiety-like behavior in male mice

P Mahbod, EP Smith, ME Fitzgerald, RL Morano… - …, 2018 - academic.oup.com
Ghrelin is a 28–amino acid polypeptide that regulates feeding, glucose metabolism, and
emotionality (stress, anxiety, and depression). Plasma ghrelin circulates as desacyl ghrelin …

A ghrelin–growth hormone axis drives stress-induced vulnerability to enhanced fear

RM Meyer, A Burgos-Robles, E Liu, SS Correia… - Molecular …, 2014 - nature.com
Hormones in the hypothalamus–pituitary–adrenal (HPA) axis mediate many of the bodily
responses to stressors, yet there is no clear relationship between the levels of these …

Growth hormone biases amygdala network activation after fear learning

B Gisabella, S Farah, X Peng, A Burgos-Robles… - Translational …, 2016 - nature.com
Prolonged stress exposure is a risk factor for developing posttraumatic stress disorder, a
disorder characterized by the 'over-encoding'of a traumatic experience. A potential …

Ghrelin regulates the hypothalamic-pituitary-adrenal axis and restricts anxiety after acute stress

SJ Spencer, L Xu, MA Clarke, M Lemus… - Biological …, 2012 - Elsevier
BACKGROUND: Ghrelin plays important roles in glucose metabolism, appetite, and body
weight regulation, and recent evidence suggests ghrelin prevents excessive anxiety under …

The protective effects of Ghrelin/GHSR on hippocampal neurogenesis in CUMS mice

HJ Huang, XR Chen, QQ Han, J Wang, A Pilot, R Yu… - …, 2019 - Elsevier
Ghrelin is an orexigenic hormone that also plays an important role in mood disorders. Our
previous studies demonstrated that ghrelin administration could protect against depression …

GHS-R1a deficiency alleviates depression-related behaviors after chronic social defeat stress

L Guo, M Niu, J Yang, L Li, S Liu, Y Sun… - Frontiers in …, 2019 - frontiersin.org
Ghrelin is an important orexigenic hormone that regulates feeding, metabolism and glucose
homeostasis in human and rodents. Ghrelin functions by binding to its receptor, the growth …

Acute but not chronic calorie restriction defends against stress-related anxiety and despair in a GHS-R1a-dependent manner

Y Lu, M Niu, X Qiu, H Cao, B Xing, Y Sun, Z Zhou… - Neuroscience, 2019 - Elsevier
Ghrelin is an important orexigenic brain-gut hormone that regulates feeding, metabolism
and glucose homeostasis in human and rodents at multiple levels. Ghrelin functions by …

Anxiolytic-like effects of increased ghrelin receptor signaling in the amygdala

M Jensen, C Ratner, O Rudenko… - International Journal …, 2016 - academic.oup.com
Background: Besides the well-known effects of ghrelin on adiposity and food intake
regulation, the ghrelin system has been shown to regulate aspects of behavior including …