In all forms of diabetes, β cell mass or function is reduced and therefore the capacity of the
pancreatic cells for regeneration or replenishment is a critical need. Diverse lines of …

Insulin-dependent diabetes is a complex multifactorial disorder characterized by loss or
dysfunction of β-cells resulting in failure of metabolic control. Even though type 1 and 2 …

Both type 1 and type 2 diabetes are characterized by a progressive loss of beta cell mass
that contributes to impaired glucose homeostasis. Although an optimal treatment option …

Diabetes is a major worldwide health problem which results from the loss and/or dysfunction
of pancreatic insulin-producing β cells in the pancreas. Therefore, there is great interest in …

The adult pancreas is only capable of limited regeneration. Unlike highly regenerative
tissues such as the skin, intestinal crypts and hematopoietic system, no dedicated adult stem …

Recent studies have revealed a surprising plasticity of pancreatic β‐cell mass. β‐cell mass
is now recognized to increase and decrease in response to physiological demand, for …

The overall conservation between mouse and human pancreatic development, islet
physiology and etiology of diabetes encourages the translation of novel β cell replacement …

Endogenous pancreatic β cell regeneration is a potential strategy for β cell expansion or
neogenesis to treat diabetes. Regeneration can occur through stimulation of existing β cell …

Introduction: The study of the endocrine compartment of the pancreas (the islets of
Langerhans) is of great translational interest, as strategies aimed at restoring its mass could …

Context: Β cell mass and function are decreased to varying degrees in both type 1 and type
2 diabetes. In the future, islet cell replacement or regeneration therapy may thus offer …