In late 2020, one of us (RAH) was approached by the late Professor Sir Peter Lachmann and
invited to join him in co-editing a collection of articles focused on the alternative pathway …

This review aimed to capture the key findings that animal models have provided around the
role of the alternative pathway and amplification loop (AP/AL) in disease. Animal models …

The factor H (FH) protein family is emerging as a complex network of proteins controlling the
fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range …

The complement system forms a network of more than 30 soluble proteins and cell-bound
receptors that perform multiple sensor and effector functions as part of the innate immune …

The complement system consists of three pathways (alternative, classical, and lectin) that
play a fundamental role in immunity and homeostasis. The multifunctional role of the …

Complement (C) originally was detected by its ability to bring about cytolysis of antibody-
sensitized bacteria and erythrocytes. Its name is derived from this ability to complement …

Over a century after the discovery of the complement system, the first complement
therapeutic was approved for the treatment of paroxysmal nocturnal hemoglobinuria (PNH) …

The increasing recognition of the complement system's association with diseases of the
inflammatory spectrum and with biomaterial and transplant-related complications has …

With every cut and bruise, every sore throat and runny nose, in all the numerous challenges
our bodies face throughout life, our host defense systems spring into action and prevent …

As a preformed defense system, complement faces a delicate challenge in providing an
immediate, forceful response to pathogens even at first encounter, while sparing host cells in …