Metabolic phenotypes, vascular complications, and premature deaths in a population of 4,197 patients with type 1 diabetes
VP Makinen, C Forsblom, LM Thorn, J Wadén… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—Poor glycemic control, elevated triglycerides, and albuminuria are associated
with vascular complications in diabetes. However, few studies have investigated combined …
with vascular complications in diabetes. However, few studies have investigated combined …
Network of vascular diseases, death and biochemical characteristics in a set of 4,197 patients with type 1 diabetes (the FinnDiane Study)
VP Mäkinen, C Forsblom, LM Thorn, J Wadén… - Cardiovascular …, 2009 - Springer
Background Cardiovascular disease is the main cause of premature death in patients with
type 1 diabetes. Patients with diabetic kidney disease have an increased risk of heart attack …
type 1 diabetes. Patients with diabetic kidney disease have an increased risk of heart attack …
Clustering of cardiovascular risk factors in type 2 diabetes mellitus: prognostic significance and tracking
J Kaukua, A Turpeinen, M Uusitupa… - Diabetes, Obesity and …, 2001 - Wiley Online Library
Aim Little attention has been paid to the prognostic significance and tracking effect of risk
factor clusters characteristic of type 2 diabetes mellitus. We studied the clustering of eight …
factor clusters characteristic of type 2 diabetes mellitus. We studied the clustering of eight …
Cardiovascular profiling in the diabetic continuum: Results from the population-based Gutenberg Health Study
VH Schmitt, A Leuschner, C Jünger, A Pinto… - Clinical Research in …, 2022 - Springer
Aims To assess the prevalence of type 2 diabetes mellitus (T2DM) and prediabetes in the
general population and to investigate the associated cardiovascular burden and clinical …
general population and to investigate the associated cardiovascular burden and clinical …
Machine learning approaches reveal metabolic signatures of incident chronic kidney disease in individuals with prediabetes and type 2 diabetes
Early and precise identification of individuals with prediabetes and type 2 diabetes (T2D) at
risk for progressing to chronic kidney disease (CKD) is essential to prevent complications of …
risk for progressing to chronic kidney disease (CKD) is essential to prevent complications of …
Stratification of diabetes in the context of comorbidities, using representation learning and topological data analysis
Diabetes is a heterogenous, multimorbid disorder with a large variation in manifestations,
trajectories, and outcomes. The aim of this study is to validate a novel machine learning …
trajectories, and outcomes. The aim of this study is to validate a novel machine learning …
Risk of typical diabetes-associated complications in different clusters of diabetic patients: analysis of nine risk factors
Objectives: Diabetic patients are often diagnosed with several comorbidities. The aim of the
present study was to investigate the relationship between different combinations of risk …
present study was to investigate the relationship between different combinations of risk …
Metabolic diversity of progressive kidney disease in 325 patients with type 1 diabetes (the FinnDiane Study)
VP Makinen, T Tynkkynen, P Soininen… - Journal of proteome …, 2012 - ACS Publications
Type 1 diabetic patients with varying severity of kidney disease were investigated to create
multimetabolite models of the disease process. Urinary albumin excretion rate was …
multimetabolite models of the disease process. Urinary albumin excretion rate was …
novel biomarkers for type 2 diabetes
TS Ahluwalia, TO Kilpeläinen, S Singh… - Frontiers in …, 2019 - frontiersin.org
Diabetes Mellitus, commonly known as diabetes, is a complex metabolic disorder
characterized by hyperglycemia over a prolonged period. The prevalence of diabetes is …
characterized by hyperglycemia over a prolonged period. The prevalence of diabetes is …
Metabolomic assessment reveals alteration in polyols and branched chain amino acids associated with present and future renal impairment in a discovery cohort of …
Background: Improved understanding of the pathophysiology causing diabetic kidney
disease (DKD) is imperative. The aim of this study was to uncover associations between …
disease (DKD) is imperative. The aim of this study was to uncover associations between …