Background The kidneys are considered one of the most susceptible organs for adverse
drug effects, particularly in post-transplant conditions. Tacrolimus (FK506), a calcineurin …

Background Calcineurin inhibitors are effective immunosuppressive agents, but associated
adverse effects such as nephrotoxicity may limit efficacy. Tacrolimus (FK506) is an …

Abstract Tacrolimus (FK506), a calcineurin inhibitor, is an effective immunosuppressive
agent mainly used to lower the risk of organ rejection after allogeneic organ transplant …

Background/Aims: The immunosuppressive drug tacrolimus (FK506) is used clinically to
reduce the rejection rate in patients with kidney transplantation; however, the resultant …

Objective To study the nephrotoxicity tacrolimus (FK506) at the therapeutic dose the
preventive effect of diltiazem (Dil), a calcium antagonist against the FK506-induced …

Objective To study the nephrotoxicity induced by first oral administration of tacrolimus
(FK506) and the prevention of diltiazem (Dil). Methods 24 Sprague-Dawley male rats were …

Background Tacrolimus (FK506) is an immunosuppressive agent and has toxic side effects
such as nephrotoxicity, hepatotoxicity, and neurotoxicity. In our study, we aimed to …

Tacrolimus (TAC), a calcineurin inhibitor (CNI), is clinically used as an immunosuppressive
agent in the transplant recipient; however, the use of TAC is greatly limited by its …

Cyclosporine A (CsA) is employed for organ transplantation and autoimmune disorders.
Nephrotoxicity is a serious side effect that hampers the therapeutic use of CsA. Hesperidin …

Background/aim The aim of this work is to study the effect of addition of ketoconazole to
experimental kidney transplanted rat treated with tacrolimus and precludes the percentage …