Design, Synthesis and Cytotoxicity of New Coumarin‐1, 2, 3‐triazole Derivatives: Evaluation of Anticancer Activity and Molecular Docking Studies

V Premsagar Miriyala, P Raj Thommandru… - Chemistry & …, 2023 - Wiley Online Library
A library of new coumarin‐1, 2, 3‐triazole hybrids 7a–l were synthesized from 4‐
(diethylamino)‐2‐hydroxybenzaldehyde precursor through a series of reactions including …

Synthesis and biological evaluation of novel triazoles linked 7-hydroxycoumarin as potent cytotoxic agents

S Farooq, A Hussain, MA Qurishi… - Anti-Cancer Agents in …, 2018 - ingentaconnect.com
Background: BacCancer is regarded as second leading cause of death worldwide.
Therefore, there is a high demand for the discovery, development and improvement of novel …

Synthesis and biological evaluation of novel isoxazoles and triazoles linked 6-hydroxycoumarin as potent cytotoxic agents

VK Tripathi, J Singh, T Ara, S Koul, S Farooq… - Bioorganic & medicinal …, 2014 - Elsevier
A new series of diverse isoxazoles and triazoles linked 6-hydroxycoumarin (1) were
synthesized using click chemistry approach. All the derivatives were subjected to 3-(4, 5 …

Synthesis of Novel 1, 2, 4‐Triazolyl Coumarin Derivatives as Potential Anticancer Agents

LH Al-Wahaibi, HM Abu-Melha… - Journal of …, 2018 - Wiley Online Library
A series of novel coumarin derivatives carrying 1, 2, 4‐triazole or 1, 2, 4‐triazolo [3, 4‐b][1, 3,
4] thiadiazole moieties were prepared and evaluated in vitro as anticancer in the human …

Synthesis of 4‐Hydroxycoumarin‐Based Triazoles/Oxadiazoles as Novel Anticancer Agents

SM Hashemi, Z Hosseini‐khah… - Chemistry & …, 2022 - Wiley Online Library
A series of novel 3‐substituted‐4‐hydroxycoumarins 7 and 8 containing (5‐aryl‐1, 3, 4‐
oxadiazol‐2‐yl) thio or (4‐amino‐5‐aryl‐4H‐1, 2, 4‐triazol‐3‐yl) thio moieties have been …

Synthesis and anticancer activities of some new coumarin derivatives including the triazole ring and their in silico molecular docking studies

E Menteşe, A Güner, E Polatlı, M Emirik… - Archiv der …, 2021 - Wiley Online Library
The synthesis, docking study, and investigation of the anticancer activities of some coumarin
derivatives containing the triazole ring are reported in this study. The newly synthesized …

Design, synthesis and cytotoxicity of novel coumarin-1, 2, 3-triazole-1, 2, 4-oxadiazole hybrids as potent anti-breast cancer agents

M Mohammadi-Khanaposhtani… - Letters in Drug …, 2019 - ingentaconnect.com
Background: This work reports design, synthesis, and in vitro cytotoxicity of novel coumarin-
1, 2, 3-triazole-1, 2, 4-oxadiazole hybrids against three breast cancer cell lines MCF-7, MDA …

Synthesis of pyrazolone derivatives of coumarin as anticancer agents

JV Patil, SS Soman, S Umar, P Girase… - …, 2024 - Wiley Online Library
Pursuing on our efforts towards searching for efficient anticancer agents herein we have
designed and synthesized pyrazolone derivatives of 7‐amino 4‐methyl coumarin and 6 …

Synthesis, antitumor activity evaluation, and DNA‐binding study of coumarin‐based agents

KM Amin, AM Taha, RF George… - Archiv Der …, 2018 - Wiley Online Library
A novel series of coumarin‐thiadiazole heterocycle derivatives was synthesized by the
nucleophilic substitution reaction. The synthesized compounds were structurally verified by …

Synthesis, in vitro anticancer and antibacterial activities and in silico studies of new 4-substituted 1, 2, 3-triazole–coumarin hybrids

TG Kraljević, A Harej, M Sedić, SK Pavelić… - European journal of …, 2016 - Elsevier
Abstract The 4-substituted 1, 2, 3-triazole core in designed coumarin hybrids (4–35) with
diverse physicochemical properties was introduced by eco-friendly copper (I)-catalyzed …