Background Factors leading to the harmful consumption of substances, like alcohol and
sucrose, involve a complex interaction of genes and the environment. While we cannot …

An individual's social environment affects alcohol intake. However, the complex interactions
between social context and alcohol intake remain understudied in preclinical models. In the …

Specific inbred mouse strains such as C57BL/6J and DBA/2J show differences in
consumption of and reaction on drugs of abuse. For example, C57BL/6J mice voluntarily …

When animals are housed in an enriched social colony environment for several months with
ad lib access to water and 10% ethanol solutions, marked individual differences in fluid …

Background Beyond yielding high blood ethanol (EtOH) concentrations (BECs), binge‐
drinking models allow examination of drinking patterns which may be associated with …

Background Binge alcohol drinking has been characterized as a key feature of alcoholism.
The drinking‐in‐the‐dark (DID) preclinical model, a procedure that promotes high levels of …

Genetic analysis of factors affecting risk to develop excessive ethanol drinking has been
extensively studied in humans and animal models for over 20 years. However, little progress …

Of the more than 100 studies that have examined relationships between excessive ethanol
consumption and the brain transcriptome, few rodent studies have examined chronic …

Because of intrinsic differences between humans and mice, no single mouse model can
represent all features of a complex human trait such as alcoholism. It is therefore necessary …

Both sexes of C57BL/6 (C57) mice consumed substantial quantities of ethanol without food
or water deprivation whether access was continuous or limited. Food deprivation increased …