CD20+ Tumor-Infiltrating Lymphocytes Have an Atypical CD27− Memory Phenotype and Together with CD8+ T Cells Promote Favorable Prognosis in Ovarian …
JS Nielsen, RA Sahota, K Milne, SE Kost… - Clinical cancer …, 2012 - AACR
Purpose: Tumor-infiltrating lymphocytes (TIL), in particular CD8+ T cells and CD20+ B cells,
are strongly associated with survival in ovarian cancer and other carcinomas. Although …
are strongly associated with survival in ovarian cancer and other carcinomas. Although …
Tumor-infiltrating lymphocytes expressing the tissue resident memory marker CD103 are associated with increased survival in high-grade serous ovarian cancer
Background: The presence of CD8+ tumor-infiltrating lymphocytes (TIL) is associated with
prolonged survival in high-grade serous ovarian cancer (HGSC) and other epithelial …
prolonged survival in high-grade serous ovarian cancer (HGSC) and other epithelial …
Single-cell profiles and prognostic impact of tumor-infiltrating lymphocytes coexpressing CD39, CD103, and PD-1 in ovarian cancer
CM Laumont, MCA Wouters, J Smazynski… - Clinical Cancer …, 2021 - AACR
Purpose: Tumor-infiltrating lymphocytes (TIL) are strongly associated with survival in most
cancers; however, the tumor-reactive subset that drives this prognostic effect remains poorly …
cancers; however, the tumor-reactive subset that drives this prognostic effect remains poorly …
Characterization of CD103+ CD8+ tissue-resident T cells in esophageal squamous cell carcinoma: may be tumor reactive and resurrected by anti-PD-1 blockade
L Han, QL Gao, XM Zhou, C Shi, GY Chen… - Cancer Immunology …, 2020 - Springer
Though therapy that promotes anti-tumor response about CD8+ tumor-infiltrating
lymphocytes (TILs) has shown great potential, clinical responses to CD8+ TILs …
lymphocytes (TILs) has shown great potential, clinical responses to CD8+ TILs …
[HTML][HTML] CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer …
FL Komdeur, MCA Wouters, HH Workel, AM Tijans… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract CD103+ tumor-infiltrating lymphocytes (TIL) have been linked to specific epithelial
infiltration and a prolonged survival in high-grade serous epithelial ovarian cancer (HGSC) …
infiltration and a prolonged survival in high-grade serous epithelial ovarian cancer (HGSC) …
Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
E Sato, SH Olson, J Ahn, B Bundy… - Proceedings of the …, 2005 - National Acad Sciences
In a recent report,[Zhang et al.(2003) N. Engl. J. Med. 348, 203–213], the presence of CD3+
tumor-infiltrating lymphocytes (TILs) was found to correlate with improved survival in …
tumor-infiltrating lymphocytes (TILs) was found to correlate with improved survival in …
PD-1 and CD103 are widely coexpressed on prognostically favorable intraepithelial CD8 T cells in human ovarian cancer
Abstract αE (CD103) β7 is a TGFβ-regulated integrin that mediates retention of lymphocytes
in peripheral tissues by binding to E-cadherin expressed on epithelial cells. We recently …
in peripheral tissues by binding to E-cadherin expressed on epithelial cells. We recently …
CD39 Identifies the CD4+ Tumor-Specific T-cell Population in Human Cancer
KE Kortekaas, SJ Santegoets, G Sturm, I Ehsan… - Cancer immunology …, 2020 - AACR
The accumulation of tumor-specific CD4+ and CD8+ effector T cells is key to an effective
antitumor response. Locally, CD4+ T cells promote the recruitment and effector function of …
antitumor response. Locally, CD4+ T cells promote the recruitment and effector function of …
Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors
T Duhen, R Duhen, R Montler, J Moses… - Nature …, 2018 - nature.com
Identifying tumor antigen-specific T cells from cancer patients has important implications for
immunotherapy diagnostics and therapeutics. Here, we show that CD103+ CD39+ tumor …
immunotherapy diagnostics and therapeutics. Here, we show that CD103+ CD39+ tumor …
Genetically driven CD39 expression shapes human tumor‐infiltrating CD8+ T‐cell functions
D Gallerano, S Ciminati, A Grimaldi… - … Journal of Cancer, 2020 - Wiley Online Library
In our study, we investigated the role of CD39 on tumor‐infiltrating CD8+ T lymphocytes
(CD8+ TILs) in colorectal, head and neck and pancreatic cancers. Partially confirming recent …
(CD8+ TILs) in colorectal, head and neck and pancreatic cancers. Partially confirming recent …
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