Cancer is a global public health concern that is characterized by the uncontrolled growth of
tumor cells. It is regarded as the subsequent cause of death after cardiovascular disease …

Impaired apoptosis is both critical in cancer development and a major barrier to effective
treatment. In response to diverse intracellular damage signals, including those evoked by …

Cancer is a primary cause of human fatality and conventional cancer therapies, eg,
chemotherapy, are often associated with adverse side-effects, tumor drug-resistance, and …

BH3-only members of the Bcl-2 intracellular protein family, which include Bim, Bmf, Bik, Bad,
Bid, Puma, Noxa and Hrk, mediate many developmentally programmed and induced …

Apoptosis has a crucial role in anti-cancer treatment. The proteins of the BCL-2 family are
core members of the apoptotic program. Thus, we postulated that alterations in the …

Proteins of the Bcl-2 family regulate apoptosis through the formation of heterodimers
between antiapoptotic or pro-survival proteins and proapoptotic or pro-death proteins …

The cell death program, apoptosis, is currently viewed as the ultimate obstacle in cancer
therapy. Inhibition of apoptosis is thought to be involved in both tumorigenesis and …

In spite of the available genetic, biochemical and structural data, precisely how the initiators
of apoptosis, the BH3-only proteins, trigger Bax and Bak to cause organellar damage …

Apoptosis triggered by exogenous and endogenous stimuli such as ultraviolet radiation,
oxidative stress, and genotoxic chemicals is a crucial phenomenon within biological …

Purpose: Proapoptotic BH3-only proteins (Bim, Bad, Bid, Puma, and Noxa) initiate apoptosis
by binding to regulatory sites on antiapoptotic Bcl-2 proteins, directly neutralizing their …