Current understanding of complement proteins as therapeutic targets for the treatment of immunoglobulin a nephropathy
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis
worldwide and a frequent cause of kidney failure. Currently, the diagnosis necessitates a …
worldwide and a frequent cause of kidney failure. Currently, the diagnosis necessitates a …
The emerging role of complement proteins as a target for therapy of IgA nephropathy
DV Rizk, N Maillard, BA Julian, B Knoppova… - Frontiers in …, 2019 - frontiersin.org
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide
and a common cause of end-stage renal disease. Evaluation of a kidney biopsy is …
and a common cause of end-stage renal disease. Evaluation of a kidney biopsy is …
Targeting complement in IgA nephropathy
F Caravaca-Fontán, E Gutiérrez… - Clinical Kidney …, 2023 - academic.oup.com
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis
worldwide. Recent years have witnessed significant improvements in the understanding of …
worldwide. Recent years have witnessed significant improvements in the understanding of …
Roles of mesangial C3 and C1q deposition in the clinical manifestations and prognosis of IgAN
S Wang, L Dong, A Qin, J Tan, X Zhou, W Qin - International …, 2023 - Elsevier
Background and aim Immunoglobulin A nephropathy (IgAN) is regarded as the most
common type of glomerulonephritis around the world and has the potential to result in renal …
common type of glomerulonephritis around the world and has the potential to result in renal …
The contribution of complement to the pathogenesis of IgA nephropathy: are complement-targeted therapies moving from rare disorders to more common diseases?
F Poppelaars, B Faria, W Schwaeble… - Journal of clinical …, 2021 - mdpi.com
Primary IgA nephropathy (IgAN) is a leading cause of chronic kidney disease and kidney
failure for which there is no disease-specific treatment. However, this could change, since …
failure for which there is no disease-specific treatment. However, this could change, since …
The complement system in IgAN: mechanistic context for therapeutic opportunities
A Duval, S Caillard… - Nephrology Dialysis …, 2023 - academic.oup.com
The complement system plays a crucial role in innate immunity, providing essential defense
against pathogens. However, uncontrolled or prolonged activation of the complement …
against pathogens. However, uncontrolled or prolonged activation of the complement …
[HTML][HTML] Is complement the main accomplice in IgA nephropathy? From initial observations to potential complement-targeted therapies
MB Le Stang, PJ Gleeson, MR Daha, RC Monteiro… - Molecular …, 2021 - Elsevier
Abstract IgA Nephropathy (IgAN) is the main cause of primary glomerulonephritis, globally.
This disease is associated with a wide range of clinical presentations, variable prognosis …
This disease is associated with a wide range of clinical presentations, variable prognosis …
[HTML][HTML] IgA nephropathy: the lectin pathway and implications for targeted therapy
J Barratt, RA Lafayette, H Zhang, V Tesar, BH Rovin… - Kidney International, 2023 - Elsevier
Many patients with immunoglobulin A nephropathy (IgAN) progress to kidney failure even
with optimal supportive care. An improved understanding of the pathophysiology of IgAN in …
with optimal supportive care. An improved understanding of the pathophysiology of IgAN in …
Complement activation in IgA nephropathy
NR Medjeral-Thomas, HT Cook… - Seminars in …, 2021 - Springer
IgA nephropathy pathogenesis is incompletely understood, and this limits the development
of disease-specific biomarkers and effective therapies. Evidence of complement activity in …
of disease-specific biomarkers and effective therapies. Evidence of complement activity in …
[HTML][HTML] Challenges in IgA nephropathy management: an era of complement inhibition
IgA nephropathy (IgAN) is the most common glomerular disease worldwide, with an
estimated annual incidence of 25 per million adults. Despite optimized supportive care …
estimated annual incidence of 25 per million adults. Despite optimized supportive care …
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